There are 5 ways to get from Clayton to Chicago by plane, train (Amtrak), bus (Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Chicago Midway International Airport
best- Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane STL - MDW
3h 23m$62–380Bus (Flixbus)
cheapest- Take the bus from St Louis Bus Station to Chicago Bus Stationbus FlixBus N2521 / ...
7h 50m$51–86Train (Amtrak)
- Take the train from St. Louis to Chicago Union Stationtrain Lincoln Service / ...
6h 13m$88–192Drive 300 mi
- Drive from Clayton to Chicagocar 300 mi
5h 14m$55–80Fly to Chicago O'Hare International Airport
- Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane STL - ORD
3h 46m$278–710
Clayton to Chicago by train (Amtrak)
Questions & Answers
The cheapest way to get from Clayton to Chicago is to bus which costs $50 - $90 and takes 7h 50m.
The fastest way to get from Clayton to Chicago is to fly which takes 3h 23m and costs $60 - $380.
No, there is no direct bus from Clayton to Chicago station. However, there are services departing from North Hanley @ Maryland Nb and arriving at Chicago Bus Station via St Louis Bus Station. The journey, including transfers, takes approximately 7h 50m.
No, there is no direct train from Clayton station to Chicago station. However, there are services departing from FORSYTH station and arriving at Chicago Union Station via St. Louis. The journey, including transfers, takes approximately 6h 13m.
The distance between Clayton and Chicago is 276 miles. The road distance is 301.7 miles.
The best way to get from Clayton to Chicago without a car is to train which takes 6h 13m and costs $85 - $200.
It takes approximately 3h 23m to get from Clayton to Chicago, including transfers.
Clayton to Chicago bus services, operated by Flixbus USA, depart from St Louis Bus Station.
Clayton to Chicago train services, operated by Amtrak, depart from St. Louis station.
The best way to get from Clayton to Chicago is to fly which takes 3h 23m and costs $60 - $380. Alternatively, you can train, which costs $85 - $200 and takes 6h 13m, you could also bus, which costs $50 - $90 and takes 7h 50m.
What companies run services between Clayton, MO, USA and Chicago, IL, USA?
Southwest Airlines flies from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW) 5 times a day. Alternatively, Amtrak operates a train from St. Louis to Chicago Union Station 5 times a day. Tickets cost $85–190 and the journey takes 4h 55m.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- $55–370
- Website
- united.com
Flights from Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $45–310
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $45–310
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from St. Louis to Chicago Union Station
- Ave. Duration
- 4h 55m
- Frequency
- 5 times a day
- Estimated price
- $85–190
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from St Louis Bus Station to Chicago Bus Station
- Ave. Duration
- 6h 5m
- Frequency
- 4 times a day
- Estimated price
- $50–85
- Schedules at
- Flixbus USA
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More Questions & Answers
Clayton to Chicago bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
Clayton to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Clayton to Chicago is 302 miles. It takes approximately 5h 14m to drive from Clayton to Chicago.
There are 1149+ hotels available in Chicago.