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How to get fromCleveland Airport (CLE) to Florenceby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

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There are 5 ways to get from Cleveland Airport (CLE) to Florence by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Florence Regional Airport (FLO)plane plane CLE - FLO
    4h 24m
    $92–460

  2. Bus

    1. Take the bus from Cleveland Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    19h 27m
    $116–232

  3. Train (Amtrak)

    1. Take the train from Cleveland Amtrak to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Florence Stationtrain train Palmetto / ...
    22h 45m
    $268–562

  4. Drive 607.8 mi

    1. Drive from Cleveland Airport (CLE) to Florencecar car 607.8 mi
    11h 4m
    $111–161

  5. Train, bus

    1. Take the train from Cleveland Amtrak to Raleigh Union Stationtrain train Floridian
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    24h 10m
    $258–530

Cleveland Airport (CLE) to Florence by subway, foot, and bus

Calendar28Weekly Services
Duration19h 27mAverage Duration
Ticket$116Cheapest Price
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Questions & Answers

Map of how to get from Cleveland Airport (CLE) to Florence.ExpandLaunch map view
  • Distance: 514.1 mi
  • Duration: 4h 24m

What companies run services between Cleveland Airport (CLE), USA and Florence, SC, USA?

American Airlines flies from Cleveland-Hopkins International Airport (CLE) to Florence Regional Airport (FLO) every 4 hours. Alternatively, you can take a subway from Airport Station to Florence Bus Station via Brookpark Station, Cleveland Bus Station, Washington Union Station, and Raleigh Bus Station in around 19h 27m.

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