There are 7 ways to get from Cleveland Clinic to Chicago by plane, train (Amtrak), bus (Amtrak), car, bus, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Cleveland-Hopkins International Airport to Chicago Midway International Airport
best- Fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW)plane CLE - MDW
3h 58m$64–398Bus to Akron, fly to Chicago O'Hare International Airport
cheapest- Take the bus from Euclid Ave & E. 100th St @ Cleveland Cl to Robert K Pfaff Transit Center - Akronbus
- Fly from Akron (CAK) to Chicago O'Hare International Airport (ORD)plane CAK - ORD
6h 25m$43–266Train (Amtrak)
- Take the train from Cleveland Amtrak to Chicago Union Stationtrain Floridian / ...
8h 16m$182–292Bus via Toledo
- Take the bus from Cleveland to Toledobus Bsb 25
- Take the bus from Toledo to Chicago Union Stationbus Amtrak Thruway Connecting Service
8h 36mDrive 346.2 mi
- Drive from Cleveland Clinic to Chicagocar 346.2 mi
5h 48m$64–92Fly Cleveland-Hopkins International Airport to Chicago O'Hare International Airport
- Fly from Cleveland-Hopkins International Airport (CLE) to Chicago O'Hare International Airport (ORD)plane CLE - ORD
4h 21m$364–808Bus (Greyhound)
- Take the bus from Cleveland Bus Station to Chicago Bus Stationbus Greyhound US0164
9h 28m$62–92
Cleveland Clinic to Chicago by foot, bus, and train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from Cleveland Clinic to Chicago is to bus which costs $60 - $95 and takes 9h 28m.
The fastest way to get from Cleveland Clinic to Chicago is to fly which takes 3h 58m and costs $60 - $400.
No, there is no direct bus from Cleveland Clinic to Chicago station. However, there are services departing from E 105Th St & Carnegie Av and arriving at Chicago Union Station via Cleveland and Toledo. The journey, including transfers, takes approximately 8h 36m.
No, there is no direct train from Cleveland Clinic to Chicago station. However, there are services departing from Cleveland Amtrak and arriving at Chicago Union Station via . The journey, including transfers, takes approximately 8h 16m.
The distance between Cleveland Clinic and Chicago is 337 miles. The road distance is 348.2 miles.
The best way to get from Cleveland Clinic to Chicago without a car is to train which takes 8h 16m and costs $180 - $300.
It takes approximately 3h 58m to get from Cleveland Clinic to Chicago, including transfers.
Cleveland Clinic to Chicago bus services, operated by Barons Bus, depart from Cleveland station.
Cleveland Clinic to Chicago train services, operated by Amtrak, depart from Cleveland Amtrak station.
The best way to get from Cleveland Clinic to Chicago is to fly which takes 3h 58m and costs $60 - $400. Alternatively, you can train, which costs $180 - $300 and takes 8h 16m, you could also bus via Toledo, which costs and takes 8h 36m.
What companies run services between Cleveland Clinic, OH, USA and Chicago, IL, USA?
Southwest Airlines and Delta fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW) 4 times a day. Alternatively, Amtrak operates a train from Cleveland Amtrak to Chicago Union Station 3 times a day. Tickets cost $180–290 and the journey takes 6h 46m.
- Website
- united.com
Flights from Cleveland-Hopkins International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 41m
- When
- Every day
- Estimated price
- $45–310
Flights from Akron to Chicago O'Hare International Airport
- Ave. Duration
- 1h 54m
- When
- Every day
- Estimated price
- $40–260
- Website
- southwest.com
Flights from Cleveland-Hopkins International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 17m
- When
- Every day
- Estimated price
- $60–390
- Website
- aa.com
Flights from Cleveland-Hopkins International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 45m
- When
- Every day
- Estimated price
- $45–310
Flights from Akron to Chicago O'Hare International Airport
- Ave. Duration
- 1h 46m
- When
- Every day
- Estimated price
- $40–260
- Website
- delta.com
Flights from Cleveland-Hopkins International Airport to Chicago Midway International Airport via Detroit
- Ave. Duration
- 3h 20m
- When
- Every day
- Estimated price
- $60–400
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Cleveland Amtrak to Chicago Union Station
- Ave. Duration
- 6h 46m
- Frequency
- 3 times a day
- Estimated price
- $180–290
- Website
- Amtrak
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Cleveland to Toledo
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $11–45
- Website
- Barons Bus
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Toledo to Chicago Union Station
- Ave. Duration
- 4h 22m
- Frequency
- Twice a week
- Website
- Amtrak
- Phone
- +1 330 762 0341
- Website
- Akron Metro
Bus from Euclid Ave & E. 100th St @ Cleveland Cl to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 1h 23m
- Frequency
- 4 times a day
- Estimated price
- $2
- Schedules at
- Akron Metro
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 25m
- Frequency
- Twice daily
- Estimated price
- $60–90
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
Cleveland Clinic to Chicago bus services, operated by Barons Bus, arrive at Toledo station.
Cleveland Clinic to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Cleveland Clinic to Chicago is 348 miles. It takes approximately 5h 48m to drive from Cleveland Clinic to Chicago.
There are 1308+ hotels available in Chicago.