There are 7 ways to get from Cleveland Clinic to Chicago by plane, train (Amtrak), bus (Amtrak), car, bus, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Cleveland-Hopkins International Airport to Chicago Midway International Airport
best- Fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW)plane CLE - MDW
3h 53m$64–378Bus to Akron, fly to Chicago O'Hare International Airport
cheapest- Take the bus from Euclid Ave & E. 100th St @ Cleveland Cl to Robert K Pfaff Transit Center - Akronbus
- Fly from Akron (CAK) to Chicago O'Hare International Airport (ORD)plane CAK - ORD
6h 24m$43–266Train (Amtrak)
- Take the train from Cleveland Amtrak to Chicago Union Stationtrain Floridian / ...
8h 16m$112–232Bus via Toledo
- Take the bus from Cleveland to Toledobus Cleveland
- Take the bus from Toledo to Chicago Union Stationbus Amtrak Thruway Connecting Service
8h 36m$98–178Drive 346.1 mi
- Drive from Cleveland Clinic to Chicagocar 346.1 mi
5h 48m$64–92Fly Cleveland-Hopkins International Airport to Chicago O'Hare International Airport
- Fly from Cleveland-Hopkins International Airport (CLE) to Chicago O'Hare International Airport (ORD)plane CLE - ORD
4h 18m$374–808Bus (Greyhound)
- Take the bus from Cleveland Bus Station to Chicago Bus Stationbus Greyhound US0164
9h 28m$58–112
Cleveland Clinic to Chicago by foot, bus, and train (Amtrak)
Questions & Answers
The cheapest way to get from Cleveland Clinic to Chicago is to bus which costs $55 - $120 and takes 9h 28m.
The fastest way to get from Cleveland Clinic to Chicago is to fly which takes 3h 53m and costs $60 - $380.
No, there is no direct bus from Cleveland Clinic to Chicago station. However, there are services departing from E 105Th St & Carnegie Av and arriving at Chicago Union Station via Cleveland and Toledo. The journey, including transfers, takes approximately 8h 36m.
No, there is no direct train from Cleveland Clinic to Chicago station. However, there are services departing from Cleveland Amtrak and arriving at Chicago Union Station via . The journey, including transfers, takes approximately 8h 16m.
The distance between Cleveland Clinic and Chicago is 337 miles. The road distance is 348.1 miles.
The best way to get from Cleveland Clinic to Chicago without a car is to train which takes 8h 16m and costs $110 - $240.
It takes approximately 3h 53m to get from Cleveland Clinic to Chicago, including transfers.
Cleveland Clinic to Chicago bus services, operated by Barons Bus, depart from Cleveland station.
Cleveland Clinic to Chicago train services, operated by Amtrak, depart from Cleveland Amtrak station.
The best way to get from Cleveland Clinic to Chicago is to fly which takes 3h 53m and costs $60 - $380. Alternatively, you can train, which costs $110 - $240 and takes 8h 16m, you could also bus via Toledo, which costs $95 - $180 and takes 8h 36m.
What companies run services between Cleveland Clinic, OH, USA and Chicago, IL, USA?
Southwest Airlines and Delta fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW) 5 times a day. Alternatively, Amtrak operates a train from Cleveland Amtrak to Chicago Union Station 3 times a day. Tickets cost $110–230 and the journey takes 6h 46m.
- Website
- united.com
Flights from Cleveland-Hopkins International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 38m
- When
- Every day
- Estimated price
- $50–320
Flights from Akron to Chicago O'Hare International Airport
- Ave. Duration
- 1h 51m
- When
- Every day
- Estimated price
- $40–260
- Website
- southwest.com
Flights from Cleveland-Hopkins International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 14m
- When
- Every day
- Estimated price
- $60–370
- Website
- aa.com
Flights from Cleveland-Hopkins International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 44m
- When
- Every day
- Estimated price
- $50–320
Flights from Akron to Chicago O'Hare International Airport
- Ave. Duration
- 1h 52m
- When
- Every day
- Estimated price
- $40–260
- Website
- delta.com
Flights from Cleveland-Hopkins International Airport to Chicago Midway International Airport via Detroit
- Ave. Duration
- 3h 15m
- When
- Every day
- Estimated price
- $60–380
Flights from Cleveland-Hopkins International Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 3h 32m
- When
- Every day
- Estimated price
- $50–320
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Cleveland Amtrak to Chicago Union Station
- Ave. Duration
- 6h 46m
- Frequency
- 3 times a day
- Estimated price
- $110–230
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 888-378-3823
- [email protected]
- Website
- baronsbus.com
Bus from Cleveland to Toledo
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $11–45
- Website
- https://baronsbus.com
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Toledo to Chicago Union Station
- Ave. Duration
- 4h 22m
- Frequency
- Twice a week
- Estimated price
- $85–130
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 330 762 0341
- Website
- akronmetro.org
Bus from Euclid Ave & E. 100th St @ Cleveland Cl to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 1h 23m
- Frequency
- 4 times a day
- Estimated price
- $2
- Schedules at
- akronmetro.org
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 25m
- Frequency
- Twice daily
- Estimated price
- $55–110
- Website
- https://www.greyhound.com/
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More Questions & Answers
Cleveland Clinic to Chicago bus services, operated by Barons Bus, arrive at Toledo station.
Cleveland Clinic to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Cleveland Clinic to Chicago is 348 miles. It takes approximately 5h 48m to drive from Cleveland Clinic to Chicago.
There are 1125+ hotels available in Chicago.