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How to get fromCleveland Clinic to Mayo Clinicby plane, train, bus, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Cleveland Clinic to Mayo Clinic by plane, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Cleveland-Hopkins International Airport to Rochester

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Rochester (RST)plane plane CLE - RST
    7h 2m
    $88–512

  2. Bus to Akron, fly to Rochester

    cheapest
    1. Take the bus from Euclid Ave & E. 100th St @ Cleveland Cl to Robert K Pfaff Transit Center - Akronbus bus
    2. Fly from Akron (CAK) to Rochester (RST)plane plane CAK - RST
    9h 27m
    $72–421

  3. Train, bus via Madison

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    18h 22m
    $188–362

  4. Train, bus

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    19h 49m
    $270–542

  5. Drive 692.6 mi

    1. Drive from Cleveland Clinic to Mayo Cliniccar car 692.6 mi
    11h 31m
    $127–183

  6. Fly Cleveland-Hopkins International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLE - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 55m
    $604–1,054

  7. Bus

    1. Take the bus from Cleveland to Chicagobus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    18h 32m
    $120–214

  8. Bus via Lake Delton

    1. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Wisconsin Dellsbus bus
    3. Take the bus from Wisconsin Dells to Rochester, MNbus bus
    19h 12m
    $128–228

Cleveland Clinic to Mayo Clinic by foot, subway, and bus

Calendar7Weekly Services
Duration19h 12mAverage Duration
Ticket$128Cheapest Price
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Questions & Answers

Map of how to get from Cleveland Clinic to Mayo Clinic.ExpandLaunch map view
  • Distance: 594.9 mi
  • Duration: 7h 2m

What companies run services between Cleveland Clinic, OH, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from Cleveland-Hopkins International Airport (CLE) to Rochester (RST) every 3 hours. Alternatively, you can take a vehicle from Cleveland Clinic to Mayo Clinic via E 105Th St & Carnegie Av, Chester Av & E 13Th St, Cleveland, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 18h 32m.

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