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How to get fromCleveland Clinic to Niagara Fallsby bus, train (Amtrak), car, plane, or bus (Greyhound)

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There are 5 ways to get from Cleveland Clinic to Niagara Falls by bus, train (Amtrak), car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, line 40 bus

    best
    1. Take the bus from Cleveland, OH to Buffalo, NYbus bus Cinncinati,OH-Buffalo
    2. Take the bus from Ellicott Street & MTC Static to Main Street & Pine Avenuebus bus 40 / ...
    6h
    $22–64

  2. Train

    1. Take the train from Cleveland Amtrak to Buffalo Depew Stationtrain train Lake Shore Limited
    2. Take the train from Buffalo Depew Station to Niagara Falls Amtrak Stationtrain train Empire Service / ...
    6h 34m
    $72–282

  3. Drive 205 mi

    1. Drive from Cleveland Clinic to Niagara Fallscar car 205 mi
    3h 49m
    $38–54

  4. Fly, bus

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Buffalo Niagara International Airport (BUF)plane plane CLE - BUF
    2. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    6h 55m
    $108–662

  5. Bus (Greyhound)

    1. Take the bus from Cleveland Bus Station to Buffalobus bus Greyhound US0171 / ...
    6h 57m
    $34–64

Cleveland Clinic to Niagara Falls by foot and bus

Calendar21Weekly Services
Duration6hAverage Duration
Ticket$22Cheapest Price
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Questions & Answers

Map of how to get from Cleveland Clinic to Niagara Falls.ExpandLaunch map view
  • Distance: 221.6 mi
  • Duration: 6h

What companies run services between Cleveland Clinic, OH, USA and Niagara Falls, NY, USA?

You can take a vehicle from Cleveland Clinic to Main Street & Pine Avenue via E 105Th St & Euclid Av, Chester Av & E 13Th St, Cleveland, OH, and Ellicott Street & MTC Static in around 6h. Alternatively, you can take a vehicle from Cleveland Clinic to Niagara Falls Amtrak Station via Cedar Av & E 93Rd St, Lakeside Ave & Convention Center, Cleveland Amtrak, and Buffalo Depew Station in around 6h 34m.

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