There are 4 ways to get from Cleveland Clinic to Syracuse by train (Amtrak), bus (Greyhound, Flixbus), car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from Cleveland Amtrak to Syracuse Regional Transportation Centertrain Lake Shore Limited
7h 8m$102–222Bus
cheapest- Take the bus from Cleveland, OH to Buffalo, NYbus Cinncinati,OH-Buffalo
- Take the bus from Buffalo to Syracusebus Adt N809 / ...
8h 42m$44–112Drive 329.4 mi
- Drive from Cleveland Clinic to Syracusecar 329.4 mi
5h 52m$61–87Fly
- Fly from Cleveland-Hopkins International Airport (CLE) to Syracuse Hancock International Airport (SYR)plane CLE - SYR
7h 9m$134–810
Cleveland Clinic to Syracuse by foot, bus, and train (Amtrak)
Questions & Answers
The cheapest way to get from Cleveland Clinic to Syracuse is to bus which costs $40 - $120 and takes 8h 42m.
The fastest way to get from Cleveland Clinic to Syracuse is to drive which takes 5h 52m and costs $60 - $90.
No, there is no direct bus from Cleveland Clinic to Syracuse. However, there are services departing from E 105Th St & Carnegie Av and arriving at Syracuse via Cleveland, OH and Buffalo. The journey, including transfers, takes approximately 8h 42m.
No, there is no direct train from Cleveland Clinic to Syracuse. However, there are services departing from Cleveland Amtrak and arriving at Syracuse Regional Transportation Center via . The journey, including transfers, takes approximately 7h 8m.
The distance between Cleveland Clinic and Syracuse is 334 miles. The road distance is 331.3 miles.
The best way to get from Cleveland Clinic to Syracuse without a car is to train which takes 7h 8m and costs $100 - $230.
It takes approximately 7h 8m to get from Cleveland Clinic to Syracuse, including transfers.
Cleveland Clinic to Syracuse bus services, operated by Barons Bus, depart from Cleveland, OH station.
Cleveland Clinic to Syracuse train services, operated by Amtrak, depart from Cleveland Amtrak station.
The best way to get from Cleveland Clinic to Syracuse is to train which takes 7h 8m and costs $100 - $230. Alternatively, you can bus, which costs $40 - $120 and takes 8h 42m, you could also fly, which costs $130 - $850 and takes 7h 9m.
What companies run services between Cleveland Clinic, OH, USA and Syracuse, NY, USA?
Amtrak operates a train from Cleveland Amtrak to Syracuse Regional Transportation Center twice daily. Tickets cost $100–220 and the journey takes 5h 38m. Alternatively, you can take a vehicle from Cleveland Clinic to Syracuse via E 105Th St & Carnegie Av, Chester Av & E 13Th St, Cleveland, OH, and Buffalo in around 8h 42m.
- Website
- delta.com
Flights from Cleveland-Hopkins International Airport to Syracuse Hancock International Airport via Detroit
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $130–800
Flights from Cleveland-Hopkins International Airport to Syracuse Hancock International Airport via New York JFK
- Ave. Duration
- 5h 29m
- When
- Every day
- Estimated price
- $150–850
Flights from Cleveland-Hopkins International Airport to Syracuse Hancock International Airport via New York La Guardia
- Ave. Duration
- 5h 47m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–850
- Website
- aa.com
Flights from Cleveland-Hopkins International Airport to Syracuse Hancock International Airport via Philadelphia
- Ave. Duration
- 5h 18m
- When
- Every day
- Estimated price
- $150–850
Flights from Cleveland-Hopkins International Airport to Syracuse Hancock International Airport via Reagan Washington
- Ave. Duration
- 5h 34m
- When
- Every day
- Estimated price
- $150–850
- Website
- united.com
Flights from Cleveland-Hopkins International Airport to Syracuse Hancock International Airport via Washington Dulles
- Ave. Duration
- 3h 48m
- When
- Every day
- Estimated price
- $150–850
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Cleveland Amtrak to Syracuse Regional Transportation Center
- Ave. Duration
- 5h 38m
- Frequency
- Twice daily
- Estimated price
- $100–220
- Website
- Amtrak
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Estimated price
- $18–60
- Website
- Barons Bus
- Phone
- +1 800-858-8555
- Website
- Trailways
Bus from Buffalo to Syracuse
- Ave. Duration
- 3h 20m
- Frequency
- Every 4 hours
- Estimated price
- $28–100
- Website
- Trailways
- Schedules at
- Trailways
- Saver
- $28–95
- Flexible
- $55–100
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Buffalo to Syracuse
- Ave. Duration
- 2h 25m
- Frequency
- 5 times a day
- Estimated price
- $24–50
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Buffalo to Syracuse
- Ave. Duration
- 3h 25m
- Frequency
- Every 4 hours
- Estimated price
- $24–45
- Schedules at
- Flixbus USA
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More Questions & Answers
Cleveland Clinic to Syracuse bus services, operated by Barons Bus, arrive at Buffalo, NY station.
Cleveland Clinic to Syracuse train services, operated by Amtrak, arrive at Syracuse Regional Transportation Center station.
Yes, the driving distance between Cleveland Clinic to Syracuse is 331 miles. It takes approximately 5h 52m to drive from Cleveland Clinic to Syracuse.
There are 94+ hotels available in Syracuse.