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How to get fromCleveland to Cape Girardeauby plane, taxi, train, bus (Greyhound), car, bus, or bus (Flixbus, Greyhound)

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There are 8 ways to get from Cleveland to Cape Girardeau by plane, taxi, train, bus (Greyhound), car, bus, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Williamson County Regional Airport, taxi

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Williamson County Regional Airport (MWA)plane plane CLE - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    6h 40m
    $222–712

  2. Bus via Chicago

    cheapest
    1. Take the bus from Cleveland to Chicagobus bus
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    17h 39m
    $105–195

  3. Train, taxi

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Carbondaletrain train
    3. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    14h 16m
    $270–507

  4. Bus

    1. Take the bus from Cleveland to Cambridgebus bus
    2. Take the bus from Cambridge, OH to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    17h 14m
    $111–225

  5. Drive  601.4 mi

    1. Drive from Cleveland to Cape Girardeaucar car 601.4 mi
    10h 34m
    $110–159

  6. Fly to Barkley Regional Airport, taxi

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Barkley Regional Airport (PAH)plane plane CLE - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    7h 33m
    $232–662

  7. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    6h 49m
    $520–944

  8. Train, bus

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    15h 41m
    $184–406

Cleveland-Hopkins International Airport (CLE) to Williamson County Regional Airport (MWA) flights

Calendar42Weekly Planes
Duration5h 45mAverage Duration
Ticket$92Cheapest Price
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Questions & Answers

Map of how to get from Cleveland to Cape Girardeau.ExpandLaunch map view
  • Distance: 526.5 mi
  • Duration: 6h 40m

What companies run services between Cleveland, OH, USA and Cape Girardeau, MO, USA?

You can take a bus from Cleveland to Cape Girardeau via Cambridge, OH, St Louis Bus Station, and Cape Girardeau in around 17h 14m.

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