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How to get fromCleveland to Florenceby plane, bus (Greyhound), train (Amtrak), car, bus, or train

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There are 6 ways to get from Cleveland to Florence by plane, bus (Greyhound), train (Amtrak), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Florence Regional Airport (FLO)plane plane CLE - FLO
    5h 51m
    $92–466

  2. Bus

    cheapest
    1. Take the bus from Cleveland, OH to Charleston, WVbus bus
    2. Take the bus from Charleston to Charlottebus bus
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Florence Bus Stationbus bus
    16h 15m
    $85–214

  3. Train (Amtrak)

    1. Take the train from Cleveland Amtrak to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Florence Stationtrain train Palmetto / ...
    20h 55m
    $270–550

  4. Drive 608.3 mi

    1. Drive from Cleveland to Florencecar car 608.3 mi
    11h 3m
    $111–161

  5. Fly to Myrtle Beach, bus

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Myrtle Beach (MYR)plane plane CLE - MYR
    2. Take the bus from Myrtle Beach to Florencebus bus
    5h 57m
    $128–470

  6. Train, bus

    1. Take the train from Cleveland Amtrak to Raleigh Union Stationtrain train Floridian
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642 / ...
    22h 5m
    $264–529

Cleveland to Florence by bus

Calendar7Weekly Buses
Duration16h 15mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

Map of how to get from Cleveland to Florence.ExpandLaunch map view
  • Distance: 525.4 mi
  • Duration: 5h 51m

What companies run services between Cleveland, OH, USA and Florence, SC, USA?

American Airlines flies from Cleveland-Hopkins International Airport (CLE) to Florence Regional Airport (FLO) every 4 hours. Alternatively, you can take a bus from Cleveland, OH to Florence Bus Station via Charleston, WV, Charleston, Charlotte Bus Station, and Camden in around 16h 15m.

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