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How to get fromCleveland to Kirksvilleby train (Amtrak), bus, train, car, plane, or shuttle

Find Transport to Kirksville

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There are 6 ways to get from Cleveland to Kirksville by train (Amtrak), bus, train, car, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    2. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    12h 55m
    $198–413

  2. Drive  661.9 mi

    cheapest
    1. Drive from Cleveland to Kirksvillecar car 661.9 mi
    12h 29m
    $121–175

  3. Bus, train

    1. Take the bus from Cleveland to Toledobus bus
    2. Take the bus from Toledo to Indianapolis, INbus bus
    3. Take the bus from Indianapolis Union Station to Galesburgbus bus
    4. Take the train from Galesburg Amtrak Station to La Plata Stationtrain train
    16h 15m
    $142–305

  4. Fly to Chicago Midway International Airport, train

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW)plane plane CLE - MDW
    2. Take the train from Chicago Union Station to La Plata Stationtrain train
    9h 43m
    $172–610

  5. Train, bus (Amtrak)

    1. Take the train from Cleveland Amtrak to Toledotrain train
    2. Take the bus from Toledo to Chicago Union Stationbus bus
    3. Take the train from Chicago Union Station to La Plata Stationtrain train
    13h 40m
    $198–376

  6. Fly to Lambert–St. Louis International Airport, shuttle

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    2. Take a shuttle bus from St. Louis to Bowling Green, Moshuttle bus
    3. Take a shuttle bus from Bowling Green, Mo to Columbiashuttle bus
    4. Take a shuttle bus from Columbia to Hy-Vee - Kirksvilleshuttle bus
    10h 20m
    $506–924

Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW) flights

Calendar26Weekly Planes
Duration1h 28mAverage Duration
Ticket$59Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cleveland to Kirksville.ExpandLaunch map view
  • Distance: 649.6 mi
  • Duration: 12h 55m

What companies run services between Cleveland, OH, USA and Kirksville, MO, USA?

You can take a train from Cleveland Amtrak to Kirksville via Chicago Union Station and La Plata Station in around 12h 55m.

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