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How to get fromCleveland to Knoxvilleby plane, bus, train, car, or bus (Greyhound)

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There are 8 ways to get from Cleveland to Knoxville by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Cleveland-Hopkins International Airport to Mcghee Tyson Airport

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Mcghee Tyson Airport (TYS)plane plane CLE - TYS
    5h 17m
    $208–922

  2. Drive 498.7 mi

    cheapest
    1. Drive from Cleveland to Knoxvillecar car 498.7 mi
    8h 20m
    $91–132

  3. Bus

    1. Take the bus from Cleveland, OH to New Yorkbus bus Cleveland-New York
    2. Take the bus from New York to Knoxvillebus bus Nyc
    21h 41m
    $270–340

  4. Train, bus via Farragut

    1. Take the train from Cleveland Amtrak to Ny Moynihan Train Hall At Penn Stationtrain train Lake Shore Limited
    2. Take the bus from New York to Knoxvillebus bus Nyc
    26h 25m
    $386–660

  5. Fly Cleveland-Hopkins International Airport to Nashville, drive

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Nashville (BNA)plane plane CLE - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 46m
    $118–342

  6. Bus to Akron, fly to Mcghee Tyson Airport

    1. Take the bus from Cleveland, OH to Robert K Pfaff Transit Center - Akronbus bus
    2. Fly from Akron (CAK) to Mcghee Tyson Airport (TYS)plane plane CAK - TYS
    7h 57m
    $178–754

  7. Train, bus

    1. Take the train from Cleveland Amtrak to Ny Moynihan Train Hall At Penn Stationtrain train Lake Shore Limited
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    26h 29m
    $341–570

  8. Bus via Brookpark Station

    1. Take the bus from Cleveland Bus Station to Port Authority Bus Terminalbus bus Greyhound US0420
    2. Take the bus from New York to Knoxvillebus bus Nyc
    28h 13m
    $270–426

Cleveland-Hopkins International Airport (CLE) to Mcghee Tyson Airport (TYS) flights

Calendar117Weekly Planes
Duration4h 23mAverage Duration
Ticket$152Cheapest Price
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Questions & Answers

Map of how to get from Cleveland to Knoxville.ExpandLaunch map view
  • Distance: 428.5 mi
  • Duration: 5h 17m

What companies run services between Cleveland, OH, USA and Knoxville, TN, USA?

Delta, Southwest Airlines, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Cleveland, OH to Knoxville via New York, New York, and Knoxville in around 21h 41m.

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