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How to get fromCleveland to La Crosseby plane, train (Amtrak), bus (Greyhound, Flixbus), car, or bus

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There are 6 ways to get from Cleveland to La Crosse by plane, train (Amtrak), bus (Greyhound, Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Cleveland-Hopkins International Airport

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to La Crosse (LSE)plane plane CLE - LSE
    5h 43m
    $102–476

  2. Bus to Akron, fly

    cheapest
    1. Take the bus from Cleveland, OH to Robert K Pfaff Transit Center - Akronbus bus
    2. Fly from Akron (CAK) to La Crosse (LSE)plane plane CAK - LSE
    9h 19m
    $87–417

  3. Train (Amtrak)

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    12h 45m
    $201–413

  4. Bus via Chicago

    1. Take the bus from Cleveland to Chicagobus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to UW La Crossebus bus
    14h 50m
    $100–183

  5. Drive 623.5 mi

    1. Drive from Cleveland to La Crossecar car 623.5 mi
    10h 23m
    $114–165

  6. Bus

    1. Take the bus from Cleveland Bus Station to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to Appleton Transit Centerbus bus
    3. Take the bus from Appleton Valley Transit to La Crosse Grand River Stationbus bus
    21h 11m
    $138–222

Cleveland to La Crosse by train (Amtrak)

Calendar21Weekly Trains
Duration12h 45mAverage Duration
Ticket$201Cheapest Price
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Questions & Answers

Map of how to get from Cleveland to La Crosse.ExpandLaunch map view
  • Distance: 527 mi
  • Duration: 5h 43m

What companies run services between Cleveland, OH, USA and La Crosse, WI, USA?

United Airlines and American Airlines fly from Cleveland-Hopkins International Airport (CLE) to La Crosse (LSE) every 4 hours. Alternatively, you can take a train from Cleveland Amtrak to La Crosse Amtrak Station via Chicago Union Station in around 12h 45m.

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