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How to get fromCleveland to La Crosseby plane, train (Amtrak), bus (Amtrak), car, bus, or bus (Flixbus, Greyhound)

Find Transport to La Crosse

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There are 6 ways to get from Cleveland to La Crosse by plane, train (Amtrak), bus (Amtrak), car, bus, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Cleveland-Hopkins International Airport

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to La Crosse (LSE)plane plane CLE - LSE
    5h 36m
    $96–476

  2. Bus to Akron, fly

    cheapest
    1. Take the bus from Cleveland to Akronbus bus
    2. Fly from Akron (CAK) to La Crosse (LSE)plane plane CAK - LSE
    7h 34m
    $82–427

  3. Train (Amtrak)

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    12h 45m
    $338–528

  4. Bus via Toledo

    1. Take the bus from Cleveland to Toledobus bus
    2. Take the bus from Toledo to Chicago Union Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to La Crossebus bus
    14h 44m

  5. Drive  623.6 mi

    1. Drive from Cleveland to La Crossecar car 623.6 mi
    10h 23m
    $114–165

  6. Bus

    1. Take the bus from Cleveland to Chicagobus bus
    2. Take the bus from Chicago Bus Station to Madisonbus bus
    3. Take the bus from Madison to La Crossebus bus
    15h 40m
    $97–182

Cleveland to La Crosse by train (Amtrak)

Calendar21Weekly Trains
Duration12h 45mAverage Duration
Ticket$338Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cleveland to La Crosse.ExpandLaunch map view
  • Distance: 527 mi
  • Duration: 5h 36m

What companies run services between Cleveland, OH, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Cleveland-Hopkins International Airport (CLE) to La Crosse (LSE) every 4 hours. Alternatively, you can take a train from Cleveland Amtrak to La Crosse Amtrak Station via Chicago Union Station in around 12h 45m.

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