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How to get fromCleveland to Louisvilleby bus (Amtrak), car, plane, train, bus, or bus (Greyhound, Amtrak)

Find Transport to Louisville

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There are 6 ways to get from Cleveland to Louisville by bus (Amtrak), car, plane, train, bus, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Cleveland to Toledobus bus
    2. Take the bus from Toledo to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    9h 45m
    $54–155

  2. Drive  346.9 mi

    1. Drive from Cleveland to Louisvillecar car 346.9 mi
    5h 50m
    $64–92

  3. Fly

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Louisville International Airport (SDF)plane plane CLE - SDF
    5h 51m
    $124–806

  4. Train, bus via Toledo

    1. Take the train from Cleveland Amtrak to Toledotrain train
    2. Take the bus from Toledo to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    10h 9m
    $102–200

  5. Train, bus

    1. Take the train from Cleveland Amtrak to Toledotrain train
    2. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    10h 24m
    $116–195

  6. Bus via Columbus

    1. Take the bus from Cleveland Ohio Greyhound Station to Columbus, Ohio Greyhound Stationbus bus
    2. Take the bus from Columbus to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    13h 31m
    $114–312

Cleveland to Louisville by bus

Calendar7Weekly Buses
Duration9h 45mAverage Duration
Ticket$54Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cleveland to Louisville.ExpandLaunch map view
  • Distance: 448.8 mi
  • Duration: 9h 45m

What companies run services between Cleveland, OH, USA and Louisville, KY, USA?

You can take a bus from Cleveland to Louisville, KY via Toledo and Indianapolis Union Station in around 9h 45m. Alternatively, Delta, Southwest Airlines, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Louisville International Airport (SDF) hourly.

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Want to know more about travelling around United States

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Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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