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How to get fromCleveland to Mayo Clinicby plane, train, bus, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Cleveland to Mayo Clinic by plane, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Cleveland-Hopkins International Airport to Rochester

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Rochester (RST)plane plane CLE - RST
    6h 38m
    $84–502

  2. Bus to Akron, fly to Rochester

    cheapest
    1. Take the bus from Cleveland, OH to Robert K Pfaff Transit Center - Akronbus bus
    2. Fly from Akron (CAK) to Rochester (RST)plane plane CAK - RST
    8h 49m
    $74–466

  3. Train, bus via Madison

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    16h 32m
    $168–333

  4. Train, bus

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    17h 50m
    $231–493

  5. Drive 688.6 mi

    1. Drive from Cleveland to Mayo Cliniccar car 688.6 mi
    11h 26m
    $126–182

  6. Fly Cleveland-Hopkins International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLE - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 26m
    $604–1,054

  7. Bus via Milwaukee

    1. Take the bus from Cleveland to Chicagobus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    17h 3m
    $118–205

  8. Bus

    1. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Madisonbus bus
    3. Take the bus from Madison to Rochesterbus bus
    19h 9m
    $122–222

Cleveland to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration16h 32mAverage Duration
Ticket$168Cheapest Price
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Questions & Answers

Map of how to get from Cleveland to Mayo Clinic.ExpandLaunch map view
  • Distance: 588.5 mi
  • Duration: 6h 38m

What companies run services between Cleveland, OH, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Cleveland-Hopkins International Airport (CLE) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Cleveland to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 17h 3m.

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