Rome2Rio

How to get fromCleveland to Mayo Clinicby plane, train, bus, car, or bus (Greyhound, Flixbus)

Find Transport to Mayo Clinic

See all options

There are 8 ways to get from Cleveland to Mayo Clinic by plane, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Cleveland-Hopkins International Airport to Rochester

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Rochester (RST)plane plane CLE - RST
    6h 27m
    $88–502

  2. Bus to Akron, fly to Rochester

    cheapest
    1. Take the bus from Cleveland, OH to Robert K Pfaff Transit Center - Akronbus bus
    2. Fly from Akron (CAK) to Rochester (RST)plane plane CAK - RST
    8h 45m
    $74–444

  3. Train, bus via Madison

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    16h 52m
    $186–353

  4. Train, bus

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    17h 55m
    $269–533

  5. Drive 688.6 mi

    1. Drive from Cleveland to Mayo Cliniccar car 688.6 mi
    11h 26m
    $126–182

  6. Fly Cleveland-Hopkins International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLE - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 21m
    $604–1,054

  7. Bus

    1. Take the bus from Cleveland to Chicagobus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    17h 3m
    $120–208

  8. Bus via Lake Delton

    1. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Wisconsin Dellsbus bus
    3. Take the bus from Wisconsin Dells to Rochester, MNbus bus
    18h 39m
    $132–242

Cleveland to Mayo Clinic by train, bus, and foot

Calendar14Weekly Services
Duration17h 55mAverage Duration
Ticket$269Cheapest Price
See schedules

Questions & Answers

Map of how to get from Cleveland to Mayo Clinic.ExpandLaunch map view
  • Distance: 588.5 mi
  • Duration: 6h 27m

What companies run services between Cleveland, OH, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from Cleveland-Hopkins International Airport (CLE) to Rochester (RST) every 3 hours. Alternatively, you can take a bus from Cleveland to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 17h 3m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers