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How to get fromCleveland to Panama Cityby plane, car, or bus

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There are 6 ways to get from Cleveland to Panama City by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Cleveland-Hopkins International Airport to Northwest Florida Beaches International Airport

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Northwest Florida Beaches International Airport (ECP)plane plane CLE - ECP
    5h 46m
    $168–632

  2. Bus to Akron, fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Take the bus from Cleveland, OH to Robert K Pfaff Transit Center - Akronbus bus
    2. Fly from Akron (CAK) to Destin–Fort Walton Beach Airport (VPS)plane plane CAK - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    6h 56m
    $95–462

  3. Drive 970.9 mi

    1. Drive from Cleveland to Panama Citycar car 970.9 mi
    16h 50m
    $178–256

  4. Fly Cleveland-Hopkins International Airport to Destin–Fort Walton Beach Airport, drive

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Destin–Fort Walton Beach Airport (VPS)plane plane CLE - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    6h 57m
    $114–570

  5. Fly Cleveland-Hopkins International Airport to Dothan Regional Airport, drive

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Dothan Regional Airport (DHN)plane plane CLE - DHN
    2. Drive from Dothan Regional Airport (DHN) to Panama Citycar car
    6h 59m
    $114–526

  6. Fly Cleveland-Hopkins International Airport to Tallahassee, drive

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Tallahassee (TLH)plane plane CLE - TLH
    2. Drive from Tallahassee (TLH) to Panama Citycar car
    7h 9m
    $150–678

Cleveland-Hopkins International Airport (CLE) to Northwest Florida Beaches International Airport (ECP) flights

Calendar76Weekly Planes
Duration5h 22mAverage Duration
Ticket$105Cheapest Price
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Questions & Answers

Map of how to get from Cleveland to Panama City.ExpandLaunch map view
  • Distance: 829.6 mi
  • Duration: 5h 46m

What companies run services between Cleveland, OH, USA and Panama City, FL, USA?

Southwest Airlines, Delta, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Northwest Florida Beaches International Airport (ECP) every 2 hours.

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Bus operators

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