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How to get fromCleveland to Saint Charlesby plane, train (Amtrak), bus (Greyhound), or car

Find Transport to Saint Charles

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There are 4 ways to get from Cleveland to Saint Charles by plane, train (Amtrak), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    4h 19m
    $122–676

  2. Drive  567.1 mi

    cheapest
    1. Drive from Cleveland to Saint Charlescar car 567.1 mi
    9h 40m
    $104–150

  3. Train (Amtrak)

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    14h 6m
    $357–551

  4. Bus

    1. Take the bus from Cleveland to Columbusbus bus Bsb 27
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    15h 52m
    $111–197

Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL) flights

Calendar47Weekly Planes
Duration3h 7mAverage Duration
Ticket$103Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cleveland to Saint Charles.ExpandLaunch map view
  • Distance: 518 mi
  • Duration: 4h 19m

What companies run services between Cleveland, OH, USA and Saint Charles, MO, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a train from Cleveland Amtrak to Saint Charles via Chicago Union Station, St. Louis, CIVIC CENTER station, NORTH HANLEY station, North Hanley Transit Center, and 4375 Rider Trail North Sb in around 14h 6m.

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