There are 9 ways to get from Cleveland to Santee by bus, plane, car, bus (Greyhound), or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Akron, fly to Charleston International Airport, drive
best- Take the bus from Cleveland, OH to Robert K Pfaff Transit Center - Akronbus
- Fly from Akron (CAK) to Charleston International Airport (CHS)plane CAK - CHS
- Drive from Charleston-Airport-CHS to Santeecar
5h 59m$123–300Drive 658.3 mi
cheapest- Drive from Cleveland to Santeecar 658.3 mi
11h 21m$121–174Bus
- Take the bus from Cleveland, OH to Charleston, WVbus
- Take the bus from Charleston to Charlottebus
- Take the bus from Charlotte to Orangeburgbus
15h 42m$155–295Train, drive (Amtrak)
- Take the train from Cleveland Amtrak to Petersburg Amtrak Stationtrain
- Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain
- Drive from Charleston Amtrak Station to Santeecar
23h 13m$304–625Fly Cleveland-Hopkins International Airport to Charlotte Douglas International Airport, bus
- Fly from Cleveland-Hopkins International Airport (CLE) to Charlotte Douglas International Airport (CLT)plane CLE - CLT
- Take the bus from Charlotte to Orangeburgbus
8h$206–784Train to Pittsburgh International Airport, fly to Charleston International Airport, drive
- Take the train from Cleveland Amtrak to Pittsburgh Amtrak Stationtrain
- Fly from Pittsburgh International Airport (PIT) to Charleston International Airport (CHS)plane PIT - CHS
- Drive from Charleston-Airport-CHS to Santeecar
8h 34m$135–546Bus to Akron, fly to Savannah, bus
- Take the bus from Cleveland, OH to Robert K Pfaff Transit Center - Akronbus
- Fly from Akron (CAK) to Savannah (SAV)plane CAK - SAV
- Take the bus from Savannah to Orangeburgbus
8h 28m$223–704Bus via Wytheville
- Take the bus from Cleveland, OH to Charleston, WVbus
- Take the bus from Charleston, WV to Wythevillebus
- Take the bus from Wytheville to Charlotte Bus Stationbus
- Take the bus from Charlotte to Orangeburgbus
16h 22m$140–330Bus #2
- Take the bus from Cleveland Bus Station to Wilson & Ferrell Shell Station - Columbusbus
- Take the bus from Columbus to Charlottebus
- Take the bus from Charlotte to Orangeburgbus
18h 32m$244–345
Akron (CAK) to Charleston International Airport (CHS) flights
Questions & Answers
The cheapest way to get from Cleveland to Santee is to drive which costs $120 - $180 and takes 11h 21m.
The fastest way to get from Cleveland to Santee is to bus and fly and drive which takes 5h 59m and costs $120 - $300.
No, there is no direct bus from Cleveland to Santee. However, there are services departing from Cleveland, OH and arriving at Orangeburg via Charleston and Charlotte. The journey, including transfers, takes approximately 15h 42m.
The distance between Cleveland and Santee is 673 miles. The road distance is 662.1 miles.
The best way to get from Cleveland to Santee without a car is to bus which takes 15h 42m and costs $150 - $300.
It takes approximately 5h 59m to get from Cleveland to Santee, including transfers.
Cleveland to Santee bus services, operated by Barons Bus, depart from Cleveland, OH station.
Cleveland to Santee bus services, operated by Barons Bus, arrive at Charleston, WV station.
Yes, the driving distance between Cleveland to Santee is 662 miles. It takes approximately 11h 21m to drive from Cleveland to Santee.
There are 40+ hotels available in Santee.
What companies run services between Cleveland, OH, USA and Santee, SC, USA?
You can take a bus from Cleveland, OH to Santee via Charleston, WV, Charleston, Charlotte, and Orangeburg in around 15h 42m.
- Website
- aa.com
Flights from Akron to Charleston International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- $70–390
Flights from Cleveland-Hopkins International Airport to Charlotte Douglas International Airport
- Ave. Duration
- 1h 43m
- When
- Every day
- Estimated price
- $110–650
Flights from Cleveland-Hopkins International Airport to Charlotte Douglas International Airport via Reagan Washington
- Ave. Duration
- 4h 6m
- When
- Tuesday, Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $130–750
Flights from Pittsburgh International Airport to Charleston International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 3h 46m
- When
- Every day
- Estimated price
- $80–440
Flights from Akron to Savannah via Charlotte Douglas International Airport
- Ave. Duration
- 3h 49m
- When
- Every day
- Estimated price
- $95–500
- Website
- flybreeze.com
Flights from Akron to Charleston International Airport
- Ave. Duration
- 1h 46m
- When
- Every day
- Estimated price
- $110–250
Flights from Pittsburgh International Airport to Charleston International Airport
- Ave. Duration
- 1h 44m
- When
- Every day
- Estimated price
- $170–1,200
Flights from Akron to Savannah
- Ave. Duration
- 2h
- When
- Thursday and Sunday
- Estimated price
- $200–1,300
- Website
- united.com
Flights from Cleveland-Hopkins International Airport to Charlotte Douglas International Airport via Washington Dulles
- Ave. Duration
- 3h 49m
- When
- Every day
- Estimated price
- $130–700
Flights from Pittsburgh International Airport to Charleston International Airport via Washington Dulles
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- $85–460
- Website
- southwest.com
Flights from Cleveland-Hopkins International Airport to Charlotte Douglas International Airport via Nashville
- Ave. Duration
- 3h 50m
- When
- Saturday
- Estimated price
- $150–800
Flights from Cleveland-Hopkins International Airport to Charlotte Douglas International Airport via Baltimore
- Ave. Duration
- 4h 5m
- When
- Saturday
- Estimated price
- $140–750
Flights from Pittsburgh International Airport to Charleston International Airport via Baltimore
- Ave. Duration
- 4h
- When
- Saturday to Friday
- Estimated price
- $90–480
- Website
- allegiantair.com
Flights from Akron to Savannah
- Ave. Duration
- 1h 46m
- When
- Thursday, Saturday, Sunday, Monday, and Friday
- Estimated price
- $95–500
- Website
- delta.com
Flights from Cleveland-Hopkins International Airport to Charlotte Douglas International Airport via Detroit
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- $130–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Cleveland Amtrak to Petersburg Amtrak Station
- Ave. Duration
- 14h 47m
- Frequency
- Once daily
- Estimated price
- $180–370
- Website
- https://www.amtrak.com/home.html
Train from Petersburg Amtrak Station to Charleston Amtrak Station
- Ave. Duration
- 6h 25m
- Frequency
- Twice daily
- Estimated price
- $110–240
- Website
- https://www.amtrak.com/home.html
Train from Cleveland Amtrak to Pittsburgh Amtrak Station
- Ave. Duration
- 3h 11m
- Frequency
- Once daily
- Estimated price
- $45–90
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 888-378-3823
- [email protected]
- Website
- baronsbus.com
Bus from Cleveland, OH to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 45 min
- Frequency
- Twice daily
- Estimated price
- $3–35
- Website
- https://baronsbus.com
Bus from Cleveland, OH to Charleston, WV
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $25–70
- Website
- https://baronsbus.com
Bus from Charleston to Charlotte
- Ave. Duration
- 5h 10m
- Frequency
- Once daily
- Estimated price
- $26–70
- Website
- https://baronsbus.com
Bus from Cleveland, OH to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 45 min
- Frequency
- Twice daily
- Estimated price
- $3–35
- Website
- https://baronsbus.com
Bus from Cleveland, OH to Charleston, WV
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $25–70
- Website
- https://baronsbus.com
Bus from Charleston, WV to Wytheville
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $13–50
- Website
- https://baronsbus.com
Bus from Wytheville to Charlotte Bus Station
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $12–50
- Website
- https://baronsbus.com
- Phone
- +1 502-368-5644 x 135
- Website
- ridewithmiller.com
Bus from Cleveland, OH to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 50 min
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- https://ridewithmiller.com
Bus from Cleveland, OH to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 50 min
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- https://ridewithmiller.com
- Phone
- +1 888 954 6287
- [email protected]
- Website
- ridegobus.com
Bus from Cleveland, OH to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 55 min
- Frequency
- Twice daily
- Estimated price
- $8–11
- Website
- https://ridegobus.com
- Book at
- https://booking.ridegobus.com
Bus from Cleveland, OH to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 55 min
- Frequency
- Twice daily
- Estimated price
- $8–11
- Website
- https://ridegobus.com
- Book at
- https://booking.ridegobus.com
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Cleveland, OH to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 50 min
- Frequency
- Once daily
- Estimated price
- $20–28
- Book at
- https://www.jeffersonlines.com
- Adult
- $20–28
Bus from Cleveland, OH to Charleston, WV
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $65–90
- Book at
- https://www.jeffersonlines.com
- Adult
- $65–90
Bus from Charleston to Charlotte
- Ave. Duration
- 5h 10m
- Frequency
- Once daily
- Estimated price
- $65–95
- Book at
- https://www.jeffersonlines.com
- Adult
- $65–95
Bus from Charlotte to Orangeburg
- Ave. Duration
- 2h 45m
- Frequency
- Twice daily
- Estimated price
- $40–60
- Book at
- https://www.jeffersonlines.com
- Adult
- $40–60
Bus from Charlotte to Orangeburg
- Ave. Duration
- 2h 45m
- Frequency
- Twice daily
- Estimated price
- $40–60
- Book at
- https://www.jeffersonlines.com
- Adult
- $40–60
Bus from Cleveland, OH to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 50 min
- Frequency
- Once daily
- Estimated price
- $20–28
- Book at
- https://www.jeffersonlines.com
- Adult
- $20–28
Bus from Savannah to Orangeburg
- Ave. Duration
- 2h
- Frequency
- Twice daily
- Estimated price
- $35–50
- Book at
- https://www.jeffersonlines.com
- Adult
- $35–50
Bus from Cleveland, OH to Charleston, WV
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $65–90
- Book at
- https://www.jeffersonlines.com
- Adult
- $65–90
Bus from Charleston, WV to Wytheville
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $40–60
- Book at
- https://www.jeffersonlines.com
- Adult
- $40–60
Bus from Wytheville to Charlotte Bus Station
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $35–55
- Book at
- https://www.jeffersonlines.com
- Adult
- $35–55
Bus from Charlotte to Orangeburg
- Ave. Duration
- 2h 45m
- Frequency
- Twice daily
- Estimated price
- $40–60
- Book at
- https://www.jeffersonlines.com
- Adult
- $40–60
Bus from Cleveland Bus Station to Wilson & Ferrell Shell Station - Columbus
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Estimated price
- $40–65
- Book at
- https://www.jeffersonlines.com
- Adult
- $40–65
Bus from Columbus to Charlotte
- Ave. Duration
- 10h 20m
- Frequency
- Once daily
- Estimated price
- $110–160
- Book at
- https://www.jeffersonlines.com
- Adult
- $110–160
Bus from Charlotte to Orangeburg
- Ave. Duration
- 2h 45m
- Frequency
- Twice daily
- Estimated price
- $40–60
- Book at
- https://www.jeffersonlines.com
- Adult
- $40–60
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Charleston to Charlotte
- Ave. Duration
- 6h 30m
- Frequency
- Once daily
- Estimated price
- $40–80
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide

















