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How to get fromCleveland to Santeeby plane, car, bus (Greyhound, Flixbus), train, taxi, or bus

Find Transport to Santee

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There are 6 ways to get from Cleveland to Santee by plane, car, bus (Greyhound, Flixbus), train, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Cleveland-Hopkins International Airport to Columbia, drive

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Columbia (CAE)plane plane CLE - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    6h 8m
    $88–468

  2. Bus

    1. Take the bus from Cleveland to Charlestonbus bus
    2. Take the bus from Charleston to Charlottebus bus
    3. Take the bus from Charlotte Bus Station to Orangeburgbus bus
    15h 43m
    $165–270

  3. Train, taxi (Amtrak)

    1. Take the train from Cleveland Amtrak to Denmark Amtrak Stationtrain train Floridian
    2. Take the taxi from Denmark Amtrak Station to Santeetaxi taxi
    24h 33m
    $684–1,014

  4. Drive  658.3 mi

    1. Drive from Cleveland to Santeecar car 658.3 mi
    11h 17m
    $121–174

  5. Bus to Akron, fly to Charleston International Airport, drive

    1. Take the bus from Cleveland to Akronbus bus
    2. Fly from Akron (CAK) to Charleston International Airport (CHS)plane plane CAK - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    6h 1m
    $88–500

  6. Fly Cleveland-Hopkins International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Charlotte Douglas International Airport (CLT)plane plane CLE - CLT
    2. Take the bus from Charlotte Bus Station to Orangeburgbus bus
    7h 56m
    $206–794

Cleveland-Hopkins International Airport (CLE) to Columbia (CAE) flights

Calendar130Weekly Planes
Duration4h 51mAverage Duration
Ticket$77Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cleveland to Santee.ExpandLaunch map view
  • Distance: 586.8 mi
  • Duration: 6h 8m

What companies run services between Cleveland, OH, USA and Santee, SC, USA?

You can take a bus from Cleveland to Santee via Charleston, Charlotte Bus Station, and Orangeburg in around 15h 43m.

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