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How to get fromColorado Springs to Knoxvilleby bus, plane, train, car, or bus (Greyhound)

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There are 9 ways to get from Colorado Springs to Knoxville by bus, plane, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Denver, fly to Mcghee Tyson Airport

    best
    1. Take the bus from The Antlers; S. Cascade to Denver International Airportbus bus
    2. Fly from Denver (DEN) to Mcghee Tyson Airport (TYS)plane plane DEN - TYS
    5h 57m
    $335–975

  2. Bus to Denver, fly to Asheville Regional Airport, drive

    cheapest
    1. Take the bus from The Antlers; S. Cascade to Denver International Airportbus bus
    2. Fly from Denver (DEN) to Asheville Regional Airport (AVL)plane plane DEN - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    8h 3m
    $172–590

  3. Bus via Indianapolis

    1. Take the bus from Colorado Springs Downtown Station to Union Stationbus bus
    2. Take the bus from Denver to Indianapolisbus bus
    3. Take the bus from Indianapolis to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 7h

  4. Bus, train

    1. Take the bus from Colorado Springs, CO to Denver, CObus bus
    2. Take the train from Denver to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 8h
    $794–1,532

  5. Drive 1,288.4 mi

    1. Drive from Colorado Springs to Knoxvillecar car 1,288.4 mi
    22h 6m
    $236–340

  6. Fly Colorado Springs Airport to Mcghee Tyson Airport

    1. Fly from Colorado Springs Airport (COS) to Mcghee Tyson Airport (TYS)plane plane COS - TYS
    7h 14m
    $259–974

  7. Bus to Denver, fly to Nashville, drive

    1. Take the bus from The Antlers; S. Cascade to Denver International Airportbus bus
    2. Fly from Denver (DEN) to Nashville (BNA)plane plane DEN - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    8h 14m
    $250–705

  8. Bus, train via Farragut

    1. Take the bus from Colorado Springs Downtown Station to Union Stationbus bus
    2. Take the train from Denver to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 8h
    $835–1,619

  9. Bus

    1. Take the bus from Colorado Springs Downtown Station to Union Stationbus bus
    2. Take the bus from Denver Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 11h
    $485–849

Denver (DEN) to Mcghee Tyson Airport (TYS) flights

Calendar49Weekly Planes
Duration3h 55mAverage Duration
Ticket$199Cheapest Price
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Questions & Answers

Map of how to get from Colorado Springs to Knoxville.ExpandLaunch map view
  • Distance: 1,258.2 mi
  • Duration: 5h 57m

What companies run services between Colorado Springs, CO, USA and Knoxville, TN, USA?

You can take a bus from Colorado Springs Downtown Station to Knoxville via Union Station, Denver, Indianapolis, Indianapolis, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 2d 7h. Alternatively, United Airlines, American Airlines, and two other airlines fly from Colorado Springs Airport (COS) to Mcghee Tyson Airport (TYS) every 2 hours.

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