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How to get fromColorado Springs to Mayo Clinicby plane, bus, car, or bus (Greyhound)

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There are 9 ways to get from Colorado Springs to Mayo Clinic by plane, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Colorado Springs Airport to Rochester

    best
    1. Fly from Colorado Springs Airport (COS) to Rochester (RST)plane plane COS - RST
    8h 57m
    $84–404

  2. Bus

    1. Take the bus from Colorado Springs Downtown Station to Union Stationbus bus
    2. Take the bus from Denver to Des Moinesbus bus
    3. Take the bus from Des Moines to Albert Leabus bus
    4. Take the bus from Albert Lea to Rochesterbus bus
    21h 42m

  3. Drive 886.5 mi

    1. Drive from Colorado Springs to Mayo Cliniccar car 886.5 mi
    15h 31m
    $162–234

  4. Bus to Denver, fly to Rochester

    1. Take the bus from The Antlers; S. Cascade to Denver International Airportbus bus
    2. Fly from Denver (DEN) to Rochester (RST)plane plane DEN - RST
    8h
    $120–455

  5. Fly Colorado Springs Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Colorado Springs Airport (COS) to Minneapolis–Saint Paul International Airport (MSP)plane plane COS - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 21m
    $151–536

  6. Bus to Denver, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from The Antlers; S. Cascade to Denver International Airportbus bus
    2. Fly from Denver (DEN) to Minneapolis–Saint Paul International Airport (MSP)plane plane DEN - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 43m
    $202–437

  7. Bus to Denver, fly to Fort Dodge Municipal Airport, drive

    1. Take the bus from The Antlers; S. Cascade to Denver International Airportbus bus
    2. Fly from Denver (DEN) to Fort Dodge Municipal Airport (FOD)plane plane DEN - FOD
    3. Drive from Fort Dodge Municipal Airport (FOD) to Mayo Cliniccar car
    8h 10m
    $135–465

  8. Bus via Des Moines

    1. Take the bus from Colorado Springs Downtown Station to Union Stationbus bus
    2. Take the bus from Denver Union Station to Des Moinesbus bus
    3. Take the bus from Des Moines to Albert Leabus bus
    4. Take the bus from Albert Lea to Rochesterbus bus
    22h 53m

  9. Bus via Omaha

    1. Take the bus from Colorado Springs Downtown Station to Union Stationbus bus
    2. Take the bus from Denver to Omaha, NEbus bus
    3. Take the bus from Omaha to Des Moinesbus bus
    4. Take the bus from Des Moines to Albert Leabus bus
    5. Take the bus from Albert Lea to Rochesterbus bus
    23h 8m

Colorado Springs Airport (COS) to Rochester (RST) flights

Calendar28Weekly Planes
Duration7h 57mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Colorado Springs to Mayo Clinic.ExpandLaunch map view
  • Distance: 747.1 mi
  • Duration: 8h 57m

What companies run services between Colorado Springs, CO, USA and Mayo Clinic, MN, USA?

American Airlines, Delta, and United Airlines fly from Colorado Springs Airport (COS) to Rochester (RST) 4 times a day. Alternatively, you can take a bus from Colorado Springs Downtown Station to Mayo Clinic via Union Station, Denver, Des Moines, Albert Lea, and Rochester in around 21h 42m.

Airlines
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