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How to get fromColorado to Knoxvilleby plane, train, bus, bus (Greyhound, Flixbus), or car

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There are 9 ways to get from Colorado to Knoxville by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Denver to Mcghee Tyson Airport

    best
    1. Fly from Denver (DEN) to Mcghee Tyson Airport (TYS)plane plane DEN - TYS
    5h 14m
    $270–1,098

  2. Fly Denver to Asheville Regional Airport, drive

    cheapest
    1. Fly from Denver (DEN) to Asheville Regional Airport (AVL)plane plane DEN - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 15m
    $122–505

  3. Train, bus

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    2d 6h
    $726–1,669

  4. Bus via Farragut

    1. Take the bus from Denver Union Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    2d 8h
    $488–738

  5. Drive  1,313.7 mi

    1. Drive from Denver to Knoxvillecar car 1,313.7 mi
    21h 47m
    $240–347

  6. Fly Colorado Springs Airport to Mcghee Tyson Airport

    1. Fly from Colorado Springs Airport (COS) to Mcghee Tyson Airport (TYS)plane plane COS - TYS
    6h 54m
    $289–1,274

  7. Fly Denver to Nashville, drive

    1. Fly from Denver (DEN) to Nashville (BNA)plane plane DEN - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 26m
    $210–552

  8. Train, bus via Ossining

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to Grand Central Terminaltrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 7h
    $682–1,547

  9. Bus

    1. Take the bus from Denver Union Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 12h
    $414–600

Denver (DEN) to Mcghee Tyson Airport (TYS) flights

Calendar54Weekly Planes
Duration3h 56mAverage Duration
Ticket$214Cheapest Price
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Comparing Your Travel Options

Map of how to get from Colorado to Knoxville.ExpandLaunch map view
  • Distance: 1,202.5 mi
  • Duration: 5h 14m

What companies run services between Colorado, USA and Knoxville, TN, USA?

Allegiant Air, United Airlines, and two other airlines fly from Denver (DEN) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a bus from Civic Center Loop to Knoxville via 16th Street & Wewatta St, Denver Union Station, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 2d 8h.

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