Rome2Rio

How to get fromColorado to Knoxvilleby plane, train, bus, bus (Greyhound, Flixbus), or car

Find Transport to Knoxville

See all options

There are 9 ways to get from Colorado to Knoxville by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Denver to Mcghee Tyson Airport

    best
    1. Fly from Denver (DEN) to Mcghee Tyson Airport (TYS)plane plane DEN - TYS
    4h 59m
    $308–1,256

  2. Fly Denver to Asheville Regional Airport, drive

    cheapest
    1. Fly from Denver (DEN) to Asheville Regional Airport (AVL)plane plane DEN - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 10m
    $123–508

  3. Train, bus

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    2d 6h
    $1,252–1,976

  4. Bus via Farragut

    1. Take the bus from Denver Union Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    2d 8h
    $532–770

  5. Drive  1,313.7 mi

    1. Drive from Denver to Knoxvillecar car 1,313.7 mi
    21h 47m
    $233–336

  6. Fly Colorado Springs Airport to Mcghee Tyson Airport

    1. Fly from Colorado Springs Airport (COS) to Mcghee Tyson Airport (TYS)plane plane COS - TYS
    7h 2m
    $329–1,374

  7. Fly Denver to Nashville, drive

    1. Fly from Denver (DEN) to Nashville (BNA)plane plane DEN - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 21m
    $211–572

  8. Train, bus via Ossining

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 6h
    $1,217–1,853

  9. Bus

    1. Take the bus from Denver Union Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 12h
    $448–632

Denver (DEN) to Mcghee Tyson Airport (TYS) flights

Calendar76Weekly Planes
Duration4h 29mAverage Duration
Ticket$252Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Colorado to Knoxville.ExpandLaunch map view
  • Distance: 1,202.6 mi
  • Duration: 4h 59m

What companies run services between Colorado, USA and Knoxville, TN, USA?

Allegiant Air, United Airlines, and three other airlines fly from Denver (DEN) to Mcghee Tyson Airport (TYS) every 2 hours. Alternatively, you can take a bus from Civic Center Loop to Knoxville via 16th Street & Wewatta St, Denver Union Station, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 2d 8h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There