Rome2Rio

How to get fromColorado to Mayo Clinicby plane, bus (Greyhound), train, bus, or car

Find Transport to Mayo Clinic

See all options

There are 9 ways to get from Colorado to Mayo Clinic by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Denver to Rochester

    best
    1. Fly from Denver (DEN) to Rochester (RST)plane plane DEN - RST
    7h 17m
    $73–421

  2. Bus

    1. Take the bus from Denver Union Station to Des Moinesbus bus
    2. Take the bus from Des Moines to Minneapolis Bus Stationbus bus
    3. Take the bus from Minneapolis to Rochesterbus bus
    23h 1m
    $175–281

  3. Train, bus

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    29h 39m
    $342–780

  4. Drive  830.8 mi

    1. Drive from Denver to Mayo Cliniccar car 830.8 mi
    14h 15m
    $152–219

  5. Fly Denver to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Denver (DEN) to Minneapolis–Saint Paul International Airport (MSP)plane plane DEN - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h
    $146–380

  6. Fly Colorado Springs Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Colorado Springs Airport (COS) to Minneapolis–Saint Paul International Airport (MSP)plane plane COS - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 15m
    $146–546

  7. Fly Denver to The Eastern Iowa Airport, drive

    1. Fly from Denver (DEN) to The Eastern Iowa Airport (CID)plane plane DEN - CID
    2. Drive from Cedar-Rapids-Airport-CID to Mayo Cliniccar car
    7h 30m
    $98–419

  8. Fly Denver to Fort Dodge Municipal Airport, drive

    1. Fly from Denver (DEN) to Fort Dodge Municipal Airport (FOD)plane plane DEN - FOD
    2. Drive from Fort Dodge Municipal Airport (FOD) to Mayo Cliniccar car
    7h 27m
    $92–398

  9. Bus via Sioux Falls

    1. Take the bus from Denver to Omahabus bus
    2. Take the bus from Omaha to Sioux Fallsbus bus
    3. Take the bus from Sioux Falls to Minneapolis-St. Paulbus bus
    4. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    27h 44m
    $325–414

Colorado to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration23h 1mAverage Duration
Ticket$175Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Colorado to Mayo Clinic.ExpandLaunch map view
  • Distance: 725.1 mi
  • Duration: 7h 17m

What companies run services between Colorado, USA and Mayo Clinic, MN, USA?

American Airlines, Delta, and two other airlines fly from Denver (DEN) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Civic Center Loop to Mayo Clinic via 16th Street & Wewatta St, Denver Union Station, Des Moines, Minneapolis, and Rochester in around 23h 1m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There