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How to get fromColorado to Mayo Clinicby plane, bus, shuttle, train, or car

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There are 8 ways to get from Colorado to Mayo Clinic by plane, bus, shuttle, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Denver to Rochester

    best
    1. Fly from Denver (DEN) to Rochester (RST)plane plane DEN - RST
    7h 10m
    $87–446

  2. Fly Colorado Springs Airport to Rochester

    cheapest
    1. Fly from Colorado Springs Airport (COS) to Rochester (RST)plane plane COS - RST
    8h 50m
    $85–444

  3. Bus, shuttle

    1. Take the bus from Denver to Omaha, NEbus bus
    2. Take the bus from Omaha, NE to Des Moinesbus bus
    3. Take the bus from Des Moines to Owatonnabus bus
    4. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    21h 18m
    $229–338

  4. Train, bus

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    30h 4m
    $408–833

  5. Drive 830.8 mi

    1. Drive from Denver to Mayo Cliniccar car 830.8 mi
    14h 15m
    $152–219

  6. Fly Denver to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Denver (DEN) to Minneapolis–Saint Paul International Airport (MSP)plane plane DEN - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h
    $168–388

  7. Fly Colorado Springs Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Colorado Springs Airport (COS) to Minneapolis–Saint Paul International Airport (MSP)plane plane COS - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 22m
    $151–536

  8. Fly Denver to Fort Dodge Municipal Airport, drive

    1. Fly from Denver (DEN) to Fort Dodge Municipal Airport (FOD)plane plane DEN - FOD
    2. Drive from Fort Dodge Municipal Airport (FOD) to Mayo Cliniccar car
    7h 27m
    $101–416

Denver (DEN) to Rochester (RST) flights

Calendar44Weekly Planes
Duration4h 32mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Colorado to Mayo Clinic.ExpandLaunch map view
  • Distance: 725 mi
  • Duration: 7h 10m

What companies run services between Colorado, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and two other airlines fly from Denver (DEN) to Rochester (RST) every 4 hours.

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