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How to get fromColorado to Mayo Clinicby plane, bus (Greyhound), train, bus, or car

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There are 10 ways to get from Colorado to Mayo Clinic by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Denver to Rochester

    best
    1. Fly from Denver (DEN) to Rochester (RST)plane plane DEN - RST
    7h 5m
    $82–436

  2. Bus

    1. Take the bus from Denver Union Station to Des Moinesbus bus
    2. Take the bus from Des Moines to Saint Paul Union Depotbus bus
    3. Take the bus from St. Paul to Rochesterbus bus
    23h 22m
    $156–288

  3. Train, bus via Milwaukee

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Rochesterbus bus
    27h 57m
    $373–768

  4. Drive 830.8 mi

    1. Drive from Denver to Mayo Cliniccar car 830.8 mi
    14h 15m
    $152–219

  5. Fly Denver to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Denver (DEN) to Minneapolis–Saint Paul International Airport (MSP)plane plane DEN - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h
    $148–388

  6. Fly Colorado Springs Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Colorado Springs Airport (COS) to Minneapolis–Saint Paul International Airport (MSP)plane plane COS - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 54m
    $151–556

  7. Fly Colorado Springs Airport to Rochester

    1. Fly from Colorado Springs Airport (COS) to Rochester (RST)plane plane COS - RST
    9h 46m
    $85–464

  8. Fly Denver to Fort Dodge Municipal Airport, drive

    1. Fly from Denver (DEN) to Fort Dodge Municipal Airport (FOD)plane plane DEN - FOD
    2. Drive from Fort Dodge Municipal Airport (FOD) to Mayo Cliniccar car
    7h 27m
    $96–416

  9. Bus via Sioux Falls

    1. Take the bus from Denver to Omaha, NEbus bus
    2. Take the bus from Omaha to Sioux Fallsbus bus
    3. Take the bus from Sioux Falls to Minneapolis-St. Paulbus bus
    4. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    27h 50m
    $328–418

  10. Train, bus

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    29h 44m
    $418–903

Colorado to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration23h 22mAverage Duration
Ticket$156Cheapest Price
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Questions & Answers

Map of how to get from Colorado to Mayo Clinic.ExpandLaunch map view
  • Distance: 725 mi
  • Duration: 7h 5m

What companies run services between Colorado, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and two other airlines fly from Denver (DEN) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from Colfax Ave & Grant St to Mayo Clinic via Denver Union Station, Des Moines, St. Paul, and Rochester in around 23h 22m.

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