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How to get fromColumbia to St. Louisby bus, plane, bus (Greyhound), train (Amtrak), car, or subway

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There are 7 ways to get from Columbia to St. Louis by bus, plane, bus (Greyhound), train (Amtrak), car, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 501 bus to Baltimore-Washington International Airport, fly

    best
    1. Take the bus from Little Patuxent Pkwy / Vantage Point Rd to Arundel Mills Mallbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    5h 23m
    $140–660

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Baltimore Downtown Bus Station to Harrisburg Bus Stationbus bus Greyhound US0430
    2. Take the bus from Harrisburg Bus Station to St Louis Bus Stationbus bus Greyhound US0421
    22h 52m
    $135–284

  3. Train via Rockville (Amtrak)

    1. Take the train from Rockville Amtrak to Chicago Union Stationtrain train Floridian
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    23h 44m
    $396–768

  4. Drive 795.7 mi

    1. Drive from Columbia to St. Louiscar car 795.7 mi
    13h 49m
    $146–210

  5. Bus to Ronald Reagan Washington National Airport, fly

    1. Take the bus from LITTLE PATUXENT PKWY & VANTAGE POINT RD nb to 13TH ST & H ST NW sbbus bus
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)plane plane DCA - STL
    5h 21m
    $168–389

  6. Bus, subway to Washington Dulles International Airport, fly

    1. Take the bus from LITTLE PATUXENT PKWY & VANTAGE POINT RD nb to 13TH ST & H ST NW sbbus bus
    2. Take the subway from Metro Center, Blue/Orange/Silver Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    3. Fly from Washington Dulles International Airport (IAD) to Lambert–St. Louis International Airport (STL)plane plane IAD - STL
    5h 57m
    $187–1,008

  7. Train (Amtrak)

    1. Take the train from Baltimore Penn Station to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    34h 25m
    $399–849

Columbia to St. Louis by bus (Greyhound)

Calendar7Weekly Buses
Duration22h 52mAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

Map of how to get from Columbia to St. Louis.ExpandLaunch map view
  • Distance: 774.8 mi
  • Duration: 5h 23m

What companies run services between Columbia, MD, USA and St. Louis, MO, USA?

You can take a bus from LITTLE PATUXENT PKWY & VANTAGE POINT RD nb to St Louis Bus Station via Baltimore St & Paca St, GREENE & BALTIMORE sb, HAINES ST & WARNER ST wb, Baltimore Downtown Bus Station, and Harrisburg Bus Station in around 22h 52m. Alternatively, you can take a vehicle from Columbia to St. Louis via Rockville Amtrak and Chicago Union Station in around 23h 44m.

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