There are 5 ways to get from Columbia to Cape Girardeau by taxi, train, bus, car, plane, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi, train, bus
best- Take the taxi from Columbia to Jefferson City Stationtaxi
- Take the train from Jefferson City Station to St. Louistrain
- Take the bus from St Louis Bus Station to Cape Girardeaubus
6h 16m$181–269Drive 223.1 mi
cheapest- Drive from Columbia to Cape Girardeaucar 223.1 mi
3h 52m$41–59Fly to Williamson County Regional Airport, taxi
- Fly from Columbia Regional Airport (COU) to Williamson County Regional Airport (MWA)plane COU - MWA
- Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi
5h 24m$250–606Bus (Greyhound)
- Take the bus from Columbia to St Louis Bus Stationbus Greyhound US0175s
- Take the bus from St Louis Bus Station to Cape Girardeaubus Greyhound US1173
6h 44m$46–87Fly to Barkley Regional Airport, taxi
- Fly from Columbia Regional Airport (COU) to Barkley Regional Airport (PAH)plane COU - PAH
- Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi
8h 40m$265–616
Columbia Regional Airport (COU) to Williamson County Regional Airport (MWA) flights
Questions & Answers
The cheapest way to get from Columbia to Cape Girardeau is to drive which costs $40 - $60 and takes 3h 52m.
The fastest way to get from Columbia to Cape Girardeau is to drive which takes 3h 52m and costs $40 - $60.
No, there is no direct bus from Columbia to Cape Girardeau. However, there are services departing from Columbia and arriving at Cape Girardeau via St Louis Bus Station. The journey, including transfers, takes approximately 6h 44m.
The distance between Columbia and Cape Girardeau is 270 miles. The road distance is 224.4 miles.
The best way to get from Columbia to Cape Girardeau without a car is to taxi and train and bus which takes 6h 16m and costs $180 - $270.
It takes approximately 6h 16m to get from Columbia to Cape Girardeau, including transfers.
Columbia to Cape Girardeau bus services, operated by Greyhound USA, depart from Columbia station.
Columbia to Cape Girardeau bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Yes, the driving distance between Columbia to Cape Girardeau is 224 miles. It takes approximately 3h 52m to drive from Columbia to Cape Girardeau.
Book your Columbia to Cape Girardeau bus tickets online with Omio.
What companies run services between Columbia, MO, USA and Cape Girardeau, MO, USA?
You can take a bus from Columbia to Cape Girardeau via St Louis Bus Station and Cape Girardeau in around 6h 44m.
- Website
- contouraviation.com
Flights from Columbia Regional Airport to Williamson County Regional Airport via Chicago O'Hare
- Ave. Duration
- 6h 4m
- When
- Every day
- Estimated price
- $65–380
- Website
- united.com
Flights from Columbia Regional Airport to Barkley Regional Airport via Chicago O'Hare
- Ave. Duration
- 7h 2m
- When
- Every day
- Estimated price
- $70–380
- Website
- aa.com
Flights from Columbia Regional Airport to Williamson County Regional Airport via Chicago O'Hare
- Ave. Duration
- 3h 57m
- When
- Every day
- Estimated price
- $65–380
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Jefferson City Station to St. Louis
- Ave. Duration
- 2h 33m
- Frequency
- Twice daily
- Estimated price
- $35–80
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $16–35
- Website
- Greyhound
Bus from Columbia to St Louis Bus Station
- Ave. Duration
- 3h 35m
- Frequency
- Twice daily
- Estimated price
- $23–45
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $16–35
- Website
- Greyhound
- Ave. Duration
- 1h 4m
- Estimated price
- $120–170
Taxi Terry's
- Phone
- +1-573-441-1414
- Website
- taxicolumbiamo.com
Ace Taxi
- Phone
- +1 216-361-4700
- Website
- acetaxi.com
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More Questions & Answers
There are 17+ hotels available in Cape Girardeau.






