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How to get fromColumbia to Knoxvilleby plane, bus (Greyhound), taxi, train, bus, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Columbia to Knoxville by plane, bus (Greyhound), taxi, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Columbia Regional Airport

    best
    1. Fly from Columbia Regional Airport (COU) to Mcghee Tyson Airport (TYS)plane plane COU - TYS
    5h 11m
    $260–936

  2. Drive 593.9 mi

    cheapest
    1. Drive from Columbia to Knoxvillecar car 593.9 mi
    10h 34m
    $109–157

  3. Bus

    1. Take the bus from Columbia to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    43h 2m
    $356–596

  4. Taxi, train, bus

    1. Take the taxi from Columbia to Jefferson City Stationtaxi taxi
    2. Take the train from Jefferson City Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    44h 7m
    $671–1,185

  5. Bus to Lambert–St. Louis International Airport, fly

    1. Take the bus from Columbia to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    9h 34m
    $211–966

  6. Bus, train

    1. Take the bus from Columbia to St Louis Bus Stationbus bus
    2. Take the train from St. Louis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    44h 15m
    $581–1,126

  7. Bus, train via Ossining

    1. Take the bus from Columbia to St Louis Bus Stationbus bus
    2. Take the train from St. Louis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    44h 52m
    $536–1,003

  8. Bus via Auburn Gresham

    1. Take the bus from Columbia to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Chicagobus bus
    3. Take the bus from Chicago to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d
    $307–473

Columbia Regional Airport (COU) to Mcghee Tyson Airport (TYS) flights

Calendar64Weekly Planes
Duration5h 29mAverage Duration
Ticket$156Cheapest Price
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Questions & Answers

Map of how to get from Columbia to Knoxville.ExpandLaunch map view
  • Distance: 523.9 mi
  • Duration: 5h 11m

What companies run services between Columbia, MO, USA and Knoxville, TN, USA?

American Airlines, United Airlines, and Allegiant Air fly from Columbia Regional Airport (COU) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Columbia to Knoxville via St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 43h 2m.

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