Rome2Rio

How to get fromColumbia to Mayo Clinicby plane, bus, shuttle, or car

Find Transport to Mayo Clinic

See all options

There are 3 ways to get from Columbia to Mayo Clinic by plane, bus, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Columbia Regional Airport (COU) to Rochester (RST)plane plane COU - RST
    5h 30m
    $121–476
  2. Drive 381.5 mi

    cheapest
    1. Drive from Columbia to Mayo Cliniccar car 381.5 mi
    7h 52m
    $70–101
  3. Bus, shuttle

    1. Take the bus from Columbia to Kansas City Bus Stationbus bus
    2. Take the bus from Kansas City to Owatonnabus bus
    3. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    13h
    $114–206

Columbia Regional Airport (COU) to Rochester (RST) flights

Calendar21Weekly Planes
Duration5h 11mAverage Duration
Ticket$66Cheapest Price
See schedules

Questions & Answers

What companies run services between Columbia, MO, USA and Mayo Clinic, MN, USA?

United Airlines and American Airlines fly from Columbia Regional Airport (COU) to Rochester (RST) 3 times a day.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound