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How to get fromColumbia to Florida Keysby plane, train, shuttle, bus (Greyhound, Flixbus), car, or bus

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There are 5 ways to get from Columbia to Florida Keys by plane, train, shuttle, bus (Greyhound, Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Columbia

    best
    1. Fly from Columbia (CAE) to Key West International Airport (EYW)plane plane CAE - EYW
    8h 17m
    $218–846

  2. Bus

    cheapest
    1. Take the bus from Assembly & Gervais South to James E Clyburn Intermodal Transportation Centerbus bus 44
    2. Take the bus from Sumter Bus Stop to Savannah Bus Stationbus bus
    3. Take the bus from Savannah Bus Station to Ft Lauderdale Broward Park & Ridebus bus
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Miami Airport Stationbus bus
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    24h 51m
    $134–240

  3. Train, shuttle

    1. Take the train from Columbia Station to Miami Amtrak Stationtrain train Floridian
    2. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus To the Keys
    24h 19m
    $407–698

  4. Drive 775.8 mi

    1. Drive from Columbia to Florida Keyscar car 775.8 mi
    13h 25m
    $142–205

  5. Bus to Augusta Regional Airport At Bush Field, fly

    1. Take the bus from Columbia, SC to Augustabus bus
    2. Fly from Augusta Regional Airport At Bush Field (AGS) to Key West International Airport (EYW)plane plane AGS - EYW
    11h 14m
    $204–510

Columbia to Florida Keys by train, foot, tram, shuttle, and bus

Calendar7Weekly Services
Duration24h 19mAverage Duration
Ticket$407Cheapest Price
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Questions & Answers

Map of how to get from Columbia to Florida Keys.ExpandLaunch map view
  • Distance: 680 mi
  • Duration: 8h 17m

What companies run services between Columbia, SC, USA and Florida Keys, FL, USA?

Delta and American Airlines fly from Columbia (CAE) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Assembly & Gervais South to Florida Keys via James E Clyburn Intermodal Transportation Center, Sumter Bus Stop, Savannah Bus Station, Ft Lauderdale Broward Park & Ride, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 24h 51m.

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