There are 6 ways to get from Columbia to Key Largo by car, plane, shuttle, train, bus, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Charleston International Airport, fly to Miami International Airport, shuttle
best- Drive from Columbia to Charleston-Airport-CHScar
- Fly from Charleston International Airport (CHS) to Miami International Airport (MIA)plane CHS - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
5h 45m$610–1,158Bus
cheapest- Take the bus from Assembly & Gervais South to James E Clyburn Intermodal Transportation Centerbus 44
- Take the bus from Sumter Bus Stop to Jacksonvillebus
- Take the bus from Jacksonville to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Key Largo Bus Stopbus
22h 1m$120–206Train, bus
- Take the train from Columbia Station to Miami Amtrak Stationtrain Floridian
- Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus 301
21h 21m$439–669Drive 694.1 mi
- Drive from Columbia to Key Largocar 694.1 mi
11h 32m$127–183Drive to Charleston International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle
- Drive from Columbia to Charleston-Airport-CHScar
- Fly from Charleston International Airport (CHS) to Fort Lauderdale–Hollywood International Airport (FLL)plane CHS - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FL
6h 13m$540–1,278Train to Savannah, fly to Miami International Airport, shuttle
- Take the train from Columbia Station to Savannah Stationtrain
- Fly from Savannah (SAV) to Miami International Airport (MIA)plane SAV - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
7h 44m$291–777
Columbia to Key Largo by train, foot, and bus
Comparing Your Travel Options
The cheapest way to get from Columbia to Key Largo is to bus which costs $120 - $210 and takes 22h 1m.
The fastest way to get from Columbia to Key Largo is to drive and fly and shuttle which takes 5h 45m and costs $600 - $1,200.
No, there is no direct bus from Columbia to Key Largo. However, there are services departing from Assembly & Gervais South and arriving at Key Largo Bus Stop via Sumter Bus Stop, Jacksonville and Miami Airport Station. The journey, including transfers, takes approximately 22h 1m.
The distance between Columbia and Key Largo is 658 miles. The road distance is 698.1 miles.
The best way to get from Columbia to Key Largo without a car is to train and bus which takes 21h 21m and costs $430 - $700.
It takes approximately 5h 45m to get from Columbia to Key Largo, including transfers.
Columbia to Key Largo bus services, operated by The COMET, depart from Assembly & Gervais South station.
Columbia to Key Largo bus services, operated by The COMET, arrive at James E Clyburn Intermodal Transportation Center station.
Yes, the driving distance between Columbia to Key Largo is 698 miles. It takes approximately 11h 32m to drive from Columbia to Key Largo.
There are 320+ hotels available in Key Largo.
What companies run services between Columbia, SC, USA and Key Largo, FL, USA?
You can take a bus from Assembly & Gervais South to Key Largo Bus Stop via James E Clyburn Intermodal Transportation Center, Sumter Bus Stop, Jacksonville, and Miami Airport Station in around 22h 1m.
- Website
- aa.com
Flights from Charleston International Airport to Miami International Airport
- Ave. Duration
- 1h 43m
- When
- Every day
- Estimated price
- $65–410
Flights from Charleston International Airport to Miami International Airport via Charlotte
- Ave. Duration
- 4h 14m
- When
- Every day
- Estimated price
- $90–490
Flights from Charleston International Airport to Fort Lauderdale–Hollywood International Airport via Charlotte
- Ave. Duration
- 4h 15m
- When
- Monday, Wednesday, Thursday, Saturday, Sunday, and Friday
- Estimated price
- $95–550
Flights from Savannah to Miami International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $75–480
- Website
- flybreeze.com
Flights from Charleston International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 38m
- When
- Monday, Friday, Thursday, and Sunday
- Estimated price
- $160–1,100
- Website
- delta.com
Flights from Charleston International Airport to Fort Lauderdale–Hollywood International Airport via Atlanta
- Ave. Duration
- 4h 4m
- When
- Every day
- Estimated price
- $100–550
- Website
- jetblue.com
Flights from Charleston International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 38m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $70–440
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Columbia Station to Miami Amtrak Station
- Ave. Duration
- 17h 34m
- Frequency
- Once daily
- Estimated price
- $430–700
- Website
- Amtrak
Train from Columbia Station to Savannah Station
- Ave. Duration
- 2h 43m
- Frequency
- Once daily
- Estimated price
- $75–120
- Website
- Amtrak
- Phone
- +1 (305) 289-9997
- [email protected]
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 15m
- Frequency
- 3 times a day
- Estimated price
- $100–130
- Website
- Keys Shuttle
Shuttle from Fort Lauderdale, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $120–150
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 15m
- Frequency
- 3 times a day
- Estimated price
- $100–130
- Website
- Keys Shuttle
- Phone
- 305-891-3131
- Website
- Miami Dade Transit
Bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largo
- Ave. Duration
- 55 min
- Frequency
- Hourly
- Estimated price
- $3
- Website
- Miami Dade Transit
- Schedules at
- World Cup Info: Miami Dade Transit
- Adult
- $3
- Phone
- +1 803-255-7100
- Website
- The COMET
Bus from Assembly & Gervais South to James E Clyburn Intermodal Transportation Center
- Ave. Duration
- 2h 1m
- Frequency
- Once daily
- Estimated price
- $2
- Schedules at
- The COMET
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Sumter Bus Stop to Jacksonville
- Ave. Duration
- 6h 25m
- Frequency
- Once daily
- Estimated price
- $50–80
- Website
- Greyhound
Bus from Jacksonville to Miami Airport Station
- Ave. Duration
- 10h 20m
- Frequency
- Once daily
- Estimated price
- $65–110
- Website
- Greyhound
Bus from Miami Airport Station to Key Largo Bus Stop
- Ave. Duration
- 1h 20m
- Frequency
- 3 times a day
- Estimated price
- $9–15
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Jacksonville to Miami Airport Station
- Ave. Duration
- 9h 15m
- Frequency
- Twice daily
- Estimated price
- $60–95
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide













