Rome2Rio

How to get fromColumbia to St. Louisby plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train

Find Transport to St. Louis

See all options

There are 6 ways to get from Columbia to St. Louis by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Columbia

    best
    1. Fly from Columbia (CAE) to Lambert–St. Louis International Airport (STL)plane plane CAE - STL
    5h 47m
    $244–1,304

  2. Drive 743.3 mi

    cheapest
    1. Drive from Columbia to St. Louiscar car 743.3 mi
    12h 30m
    $136–196

  3. Bus via Sumter

    1. Take the bus from Assembly & Gervais South to James E Clyburn Intermodal Transportation Centerbus bus 44
    2. Take the bus from Sumter to Atlantabus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    19h 44m

  4. Train (Amtrak)

    1. Take the train from Columbia Station to Chicago Union Stationtrain train Floridian
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    35h 9m
    $506–1,030

  5. Train to Savannah, fly

    1. Take the train from Columbia Station to Savannah Stationtrain train
    2. Fly from Savannah (SAV) to Lambert–St. Louis International Airport (STL)plane plane SAV - STL
    6h 43m
    $238–944

  6. Bus

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    19h 53m
    $144–276

Columbia (CAE) to Lambert–St. Louis International Airport (STL) flights

Calendar141Weekly Planes
Duration5h 29mAverage Duration
Ticket$248Cheapest Price
See schedules

Questions & Answers

Map of how to get from Columbia to St. Louis.ExpandLaunch map view
  • Distance: 633.9 mi
  • Duration: 5h 47m

What companies run services between Columbia, SC, USA and St. Louis, MO, USA?

Delta, American Airlines, and United Airlines fly from Columbia (CAE) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Assembly & Gervais South to St Louis Bus Station via James E Clyburn Intermodal Transportation Center, Sumter, and Atlanta Bus Station in around 19h 44m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers