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How to get fromColumbus to St. Louisby plane, bus (Greyhound, Flixbus), car, bus, taxi, or bus (Greyhound)

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There are 7 ways to get from Columbus to St. Louis by plane, bus (Greyhound, Flixbus), car, bus, taxi, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Columbus Airport

    best
    1. Fly from Columbus Airport (CSG) to Lambert–St. Louis International Airport (STL)plane plane CSG - STL
    6h 21m
    $101–556

  2. Bus

    1. Take the bus from Groome Transportation - Columbus to Atlanta Airportbus bus Groome Transportation
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    15h 5m
    $124–229

  3. Drive 621.3 mi

    1. Drive from Columbus to St. Louiscar car 621.3 mi
    11h 5m
    $114–164

  4. Bus to Hartsfield-Jackson Atlanta International Airport, fly

    1. Take the bus from National Infantry Museum to Atlanta Airportbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Lambert–St. Louis International Airport (STL)plane plane ATL - STL
    6h 20m
    $144–679

  5. Drive to Northwest Florida Beaches International Airport, fly

    1. Drive from Columbus to Northwest Florida Beaches International Airport (ECP)car car
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL)plane plane ECP - STL
    5h 57m
    $136–600

  6. Taxi, bus to Montgomery Regional Airport, fly

    1. Take the taxi from Columbus to Opelika 4th Street Stationtaxi taxi
    2. Take the bus from Opelika 4th Street Station to Montgomery Intermodal Centerbus bus
    3. Fly from Montgomery Regional Airport (MGM) to Lambert–St. Louis International Airport (STL)plane plane MGM - STL
    9h 24m
    $178–649

  7. Bus via Evansville

    1. Take the bus from Groome Transportation - Columbus to Atlanta Airportbus bus
    2. Take the bus from Atlanta Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    16h 50m
    $129–239

Columbus Airport (CSG) to Lambert–St. Louis International Airport (STL) flights

Calendar16Weekly Planes
Duration4h 21mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Columbus to St. Louis.ExpandLaunch map view
  • Distance: 548.8 mi
  • Duration: 6h 21m

What companies run services between Columbus, GA, USA and St. Louis, MO, USA?

Delta flies from Columbus Airport (CSG) to Lambert–St. Louis International Airport (STL) twice daily. Alternatively, you can take a bus from Metra Transfer Center to St Louis Bus Station via North Lake Loop & Bear Ln., Groome Transportation - Columbus, Atlanta Airport, Airport Station, Garnett Station, and Atlanta Bus Station in around 15h 5m.

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