Rome2Rio

How to get fromColumbus to Mayo Clinicby taxi, plane, train, bus, car, or bus (Greyhound, Flixbus)

Find Transport to Mayo Clinic

See all options

There are 10 ways to get from Columbus to Mayo Clinic by taxi, plane, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Indianapolis, fly to Rochester

    best
    1. Take the taxi from Columbus to Indianapolis-Airport-INDtaxi taxi
    2. Fly from Indianapolis (IND) to Rochester (RST)plane plane IND - RST
    6h 11m
    $194–596

  2. Drive to Covington, fly to Rochester

    cheapest
    1. Drive from Columbus to Covington (CVG)car car
    2. Fly from Covington (CVG) to Rochester (RST)plane plane CVG - RST
    6h 46m
    $101–541

  3. Taxi, train, bus via Milwaukee

    1. Take the taxi from Columbus to Indianapolistaxi taxi
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    4. Take the bus from Milwaukee to Rochesterbus bus
    15h 6m
    $259–411

  4. Taxi, bus

    1. Take the taxi from Columbus to Bloomingtontaxi taxi
    2. Take the bus from Bloomington to Chicago Bus Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    16h 8m
    $195–296

  5. Taxi, train, bus

    1. Take the taxi from Columbus to Indianapolistaxi taxi
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    16h 53m
    $320–561

  6. Taxi to Indianapolis, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the taxi from Columbus to Indianapolis-Airport-INDtaxi taxi
    2. Fly from Indianapolis (IND) to Minneapolis–Saint Paul International Airport (MSP)plane plane IND - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 47m
    $675–1,298

  7. Drive to Covington, fly to Minneapolis–Saint Paul International Airport, bus

    1. Drive from Columbus to Covington (CVG)car car
    2. Fly from Covington (CVG) to Minneapolis–Saint Paul International Airport (MSP)plane plane CVG - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 44m
    $517–1,173

  8. Bus

    1. Take the bus from TA Travel Center - Seymour to Indianapolisbus bus
    2. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    16h 50m
    $195–370

  9. Taxi, train, bus #2

    1. Take the taxi from Columbus to County Line Rd at Greenwood Park Malltaxi taxi
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    17h 42m
    $221–362

  10. Drive 571.4 mi

    1. Drive from Columbus to Mayo Cliniccar car 571.4 mi
    9h 41m
    $105–151

Indianapolis (IND) to Rochester (RST) flights

Calendar53Weekly Planes
Duration4h 44mAverage Duration
Ticket$71Cheapest Price
See schedules

Questions & Answers

Map of how to get from Columbus to Mayo Clinic.ExpandLaunch map view
  • Distance: 493.4 mi
  • Duration: 6h 11m

What companies run services between Columbus, IN, USA and Mayo Clinic, MN, USA?

You can take a vehicle from Columbus to Mayo Clinic via TA Travel Center - Seymour, Indianapolis, Lafayette Rd & Office Plaza Blvd, Ctc-R, Indianapolis Union Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 16h 50m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound