What is the cheapest way to get from Columbus to St. Louis?

The cheapest way to get from Columbus to St. Louis is to drive which costs $70 - $110 and takes 7h 35m.

What is the fastest way to get from Columbus to St. Louis?

The fastest way to get from Columbus to St. Louis is to fly which takes 4h 48m and costs $140 - $600.

How far is it from Columbus to St. Louis?

The distance between Columbus and St. Louis is 407 miles. The road distance is 433.7 miles.

How long does it take to get from Columbus to St. Louis?

It takes approximately 4h 48m to get from Columbus to St. Louis, including transfers.

Can I drive from Columbus to St. Louis?

Yes, the driving distance between Columbus to St. Louis is 434 miles. It takes approximately 7h 35m to drive from Columbus to St. Louis.

Where can I stay near St. Louis?

There are 567+ hotels available in St. Louis.

Columbus to St. Louis - 4 ways to travel via plane, car, and bus

How to get fromColumbus to St. Louis

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There are 4 ways to get from Columbus to St. Louis by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly from Golden Triangle Regional Airport
best
1. Fly from Golden Triangle Regional Airport (GTR) to Lambert–St. Louis International Airport (STL)plane GTR - STL
4h 48m
$142–599
Drive, bus
cheapest
1. Drive from Columbus to Tupelocar
2. Take the bus from Tupelo to Memphis Bus Stationbus
3. Take the bus from Memphis Bus Station to St Louis Bus Stationbus
9h 16m
$74–123
Drive 431.2 mi
1. Drive from Columbus to St. Louiscar 431.2 mi
7h 35m
$74–107
Drive, bus to Birmingham–Shuttlesworth International Airport, fly
1. Drive from Columbus to Embassy Suites by Hilton Tuscaloosa Alabama Dowtowncar
2. Take the bus from Embassy Suites by Hilton Tuscaloosa Alabama Dowtown to Birmingham-Shuttlesworthbus
3. Fly from Birmingham–Shuttlesworth International Airport (BHM) to Lambert–St. Louis International Airport (STL)plane BHM - STL
7h 41m
$138–562

Golden Triangle Regional Airport (GTR) to Lambert–St. Louis International Airport (STL) flights

20Weekly Planes

4h 53mAverage Duration

$102Cheapest Price

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Comparing Your Travel Options

Map of how to get from Columbus to St. Louis.

Launch map view

Distance: 405 mi
Duration: 4h 48m

What companies run services between Columbus, MS, USA and St. Louis, MO, USA?

Delta and American Airlines fly from Golden Triangle Regional Airport (GTR) to Lambert–St. Louis International Airport (STL) 3 times a day.

Airlines

Bus operators

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How to get fromColumbus to St. Louisby plane, car, or bus

There are 4 ways to get from Columbus to St. Louis by plane, car, or bus

Fly from Golden Triangle Regional Airport

Drive, bus

Drive 431.2 mi

Drive, bus to Birmingham–Shuttlesworth International Airport, fly