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How to get fromColumbus to Cape Girardeauby bus (Greyhound), car, plane, taxi, bus, or train

Find Transport to Cape Girardeau

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There are 7 ways to get from Columbus to Cape Girardeau by bus (Greyhound), car, plane, taxi, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus Greyhound US1173
    12h 14m
    $86–163

  2. Drive 460.1 mi

    cheapest
    1. Drive from Columbus to Cape Girardeaucar car 460.1 mi
    8h 13m
    $84–122

  3. Fly to Williamson County Regional Airport, taxi

    1. Fly from John Glenn Columbus International Airport (CMH) to Williamson County Regional Airport (MWA)plane plane CMH - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    7h 21m
    $222–663

  4. Bus, train, taxi

    1. Take the bus from Columbus to Dayton Trotwood Bus Stationbus bus
    2. Take the bus from Dayton Trotwood Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Champaign Intermodal Trans Ctrbus bus
    4. Take the train from Champaign-Urbana to Carbondaletrain train
    5. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    12h 14m
    $198–333

  5. Fly to Barkley Regional Airport, taxi

    1. Fly from John Glenn Columbus International Airport (CMH) to Barkley Regional Airport (PAH)plane plane CMH - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    8h 10m
    $232–673

  6. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    7h 4m
    $828–950

  7. Fly to Cape Girardeau Municipal Airport

    1. Fly from John Glenn Columbus International Airport (CMH) to Cape Girardeau Municipal Airport (CGI)plane plane CMH - CGI
    6h 38m
    $185–781

John Glenn Columbus International Airport (CMH) to Williamson County Regional Airport (MWA) flights

Calendar26Weekly Planes
Duration5h 5mAverage Duration
Ticket$90Cheapest Price
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Questions & Answers

Map of how to get from Columbus to Cape Girardeau.ExpandLaunch map view
  • Distance: 536 mi
  • Duration: 12h 14m

What companies run services between Columbus, OH, USA and Cape Girardeau, MO, USA?

You can take a bus from Columbus to Cape Girardeau via St Louis Bus Station and Cape Girardeau in around 12h 14m. Alternatively, American Airlines, Corporate Flight Management Inc, and Southwest Airlines fly from John Glenn Columbus International Airport (CMH) to Cape Girardeau Municipal Airport (CGI) twice daily.

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