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How to get fromColumbus to Florenceby plane, bus (Greyhound), car, bus, or train

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There are 4 ways to get from Columbus to Florence by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from John Glenn Columbus International Airport (CMH) to Florence Regional Airport (FLO)plane plane CMH - FLO
    5h 25m
    $87–466

  2. Bus

    cheapest
    1. Take the bus from Columbus - Mound St to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    14h 35m
    $85–165

  3. Drive 523.4 mi

    1. Drive from Columbus to Florencecar car 523.4 mi
    9h 41m
    $96–138

  4. Bus, train

    1. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    2. Take the bus from Winston-Salem to Fayettevillebus bus
    3. Take the train from Fayetteville Amtrak Station to Florence Stationtrain train
    16h 36m
    $108–218

Columbus to Florence by bus

Calendar7Weekly Buses
Duration14h 35mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

Map of how to get from Columbus to Florence.ExpandLaunch map view
  • Distance: 452 mi
  • Duration: 5h 25m

What companies run services between Columbus, OH, USA and Florence, SC, USA?

American Airlines flies from John Glenn Columbus International Airport (CMH) to Florence Regional Airport (FLO) 6 times a week. Alternatively, you can take a bus from Columbus - Mound St to Florence Bus Station via Charlotte Bus Station and Camden in around 14h 35m.

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