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How to get fromColumbus to La Crosseby plane, bus, train, car, or bus (Flixbus)

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There are 6 ways to get from Columbus to La Crosse by plane, bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from John Glenn Columbus International Airport (CMH) to La Crosse (LSE)plane plane CMH - LSE
    6h 11m
    $101–496

  2. Bus, train

    1. Take the bus from Columbus to Chicago Bus Stationbus bus FlixBus 2511 / ...
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    13h 38m
    $140–279

  3. Bus, train via Toledo

    1. Take the bus from Columbus - Mound St to Toledobus bus
    2. Take the train from Toledo to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train
    14h 27m
    $176–379

  4. Drive 591.6 mi

    1. Drive from Columbus to La Crossecar car 591.6 mi
    10h 54m
    $108–156

  5. Bus

    1. Take the bus from Columbus to Milwaukee Intermodal Stationbus bus FlixBus 2511
    2. Take the bus from Milwaukee to La Crossebus bus Jefferson Lines 966
    14h 40m
    $119–186

  6. Bus via Chicago

    1. Take the bus from Columbus to Chicago Bus Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to La Crossebus bus
    15h 35m
    $115–199

Columbus to La Crosse by bus, foot, and train

Calendar15Weekly Services
Duration13h 38mAverage Duration
Ticket$140Cheapest Price
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Questions & Answers

Map of how to get from Columbus to La Crosse.ExpandLaunch map view
  • Distance: 526.9 mi
  • Duration: 6h 11m

What companies run services between Columbus, OH, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from John Glenn Columbus International Airport (CMH) to La Crosse (LSE) every 4 hours. Alternatively, you can take a bus from Columbus to La Crosse via Milwaukee Intermodal Station and Milwaukee in around 14h 40m.

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