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How to get fromColumbus to Mayo Clinicby plane, bus (Flixbus), car, or bus

Find Transport to Mayo Clinic

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There are 5 ways to get from Columbus to Mayo Clinic by plane, bus (Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from John Glenn Columbus International Airport (CMH) to Rochester (RST)plane plane CMH - RST
    6h 54m
    $88–523

  2. Bus

    1. Take the bus from Columbus to Milwaukee Intermodal Stationbus bus FlixBus 2511
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    16h 48m
    $139–211

  3. Drive 656.7 mi

    1. Drive from Columbus to Mayo Cliniccar car 656.7 mi
    11h 57m
    $120–174

  4. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from John Glenn Columbus International Airport (CMH) to Minneapolis–Saint Paul International Airport (MSP)plane plane CMH - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 41m
    $474–1,055

  5. Bus via Chicago

    1. Take the bus from Columbus - Mound St to Chicagobus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    17h 53m
    $108–207

Columbus to Mayo Clinic by bus and foot

Calendar6Weekly Services
Duration16h 48mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

Map of how to get from Columbus to Mayo Clinic.ExpandLaunch map view
  • Distance: 584.2 mi
  • Duration: 6h 54m

What companies run services between Columbus, OH, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from John Glenn Columbus International Airport (CMH) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Columbus to Mayo Clinic via Milwaukee Intermodal Station, Milwaukee, and Rochester in around 16h 48m.

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