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How to get fromColumbus to Mississippiby plane, bus (Amtrak, Greyhound, Flixbus), bus, train, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Columbus to Mississippi by plane, bus (Amtrak, Greyhound, Flixbus), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Memphis

    best
    1. Fly from John Glenn Columbus International Airport (CMH) to Memphis (MEM)plane plane CMH - MEM
    5h 23m
    $164–880

  2. Bus via Louisville

    cheapest
    1. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus
    2. Take the bus from Louisville, KY to Nashvillebus bus
    3. Take the bus from Nashville Bus Station to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Jacksonbus bus
    17h 50m
    $111–230

  3. Bus, train via Indianapolis

    1. Take the bus from Columbus to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Champaign Intermodal Trans Ctrbus bus
    3. Take the train from Champaign-Urbana to Jacksontrain train
    21h
    $234–497

  4. Drive 765.8 mi

    1. Drive from Columbus to Jacksoncar car 765.8 mi
    13h 39m
    $140–202

  5. Fly to Jackson/Vicksburg

    1. Fly from John Glenn Columbus International Airport (CMH) to Jackson/Vicksburg (JAN)plane plane CMH - JAN
    5h 43m
    $137–603

  6. Fly to Gulfport-Biloxi Regional Airport

    1. Fly from John Glenn Columbus International Airport (CMH) to Gulfport-Biloxi Regional Airport (GPT)plane plane CMH - GPT
    5h 53m
    $143–717

  7. Bus

    1. Take the bus from Columbus to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Memphis Bus Stationbus bus
    3. Take the bus from Memphis Bus Station to Jacksonbus bus
    20h 5m
    $122–236

  8. Bus, train

    1. Take the bus from Columbus - Mound St to Toledobus bus
    2. Take the train from Toledo to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Jacksontrain train
    25h 3m
    $321–689

Columbus to Mississippi by bus

Calendar7Weekly Buses
Duration17h 50mAverage Duration
Ticket$111Cheapest Price
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Questions & Answers

Map of how to get from Columbus to Mississippi.ExpandLaunch map view
  • Distance: 537.4 mi
  • Duration: 5h 23m

What companies run services between Columbus, OH, USA and Mississippi, USA?

Southwest Airlines, Delta, and two other airlines fly from John Glenn Columbus International Airport (CMH) to Memphis (MEM) hourly. Alternatively, you can take a bus from Columbus - Downtown - Mound St to Jackson via Louisville, KY, Nashville Bus Station, and Memphis Bus Station in around 17h 50m.

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