There are 4 ways to get from Columbus to Santee by plane, car, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Charleston International Airport, drive
best- Fly from John Glenn Columbus International Airport (CMH) to Charleston International Airport (CHS)plane CMH - CHS
- Drive from Charleston-Airport-CHS to Santeecar
4h 33m$82–519Bus
- Take the bus from Columbus - Mound St to Charlotte Bus Stationbus Columbus
- Take the bus from Charlotte Bus Station to Orangeburgbus Greyhound US0644S / ...
15h 28m$171–278Drive 573.3 mi
- Drive from Columbus to Santeecar 573.3 mi
9h 59m$105–152Fly to Columbia, drive
- Fly from John Glenn Columbus International Airport (CMH) to Columbia (CAE)plane CMH - CAE
- Drive from Columbia-Airport-CAE to Santeecar
6h 22m$87–469
John Glenn Columbus International Airport (CMH) to Charleston International Airport (CHS) flights
Questions & Answers
The cheapest way to get from Columbus to Santee is to drive which costs $100 - $160 and takes 9h 59m.
The fastest way to get from Columbus to Santee is to fly and drive which takes 4h 33m and costs $80 - $550.
No, there is no direct bus from Columbus to Santee. However, there are services departing from Columbus - Mound St and arriving at Orangeburg via Charlotte Bus Station. The journey, including transfers, takes approximately 15h 28m.
The distance between Columbus and Santee is 592 miles. The road distance is 576.7 miles.
The best way to get from Columbus to Santee without a car is to bus which takes 15h 28m and costs $170 - $280.
It takes approximately 4h 33m to get from Columbus to Santee, including transfers.
Columbus to Santee bus services, operated by Barons Bus, depart from Columbus - Mound St station.
Columbus to Santee bus services, operated by Barons Bus, arrive at Charlotte Bus Station.
Yes, the driving distance between Columbus to Santee is 577 miles. It takes approximately 9h 59m to drive from Columbus to Santee.
There are 29+ hotels available in Santee.
What companies run services between Columbus, OH, USA and Santee, SC, USA?
You can take a bus from Columbus - Mound St to Santee via Charlotte Bus Station and Orangeburg in around 15h 28m.
- Website
- aa.com
Flights from John Glenn Columbus International Airport to Charleston International Airport via Charlotte
- Ave. Duration
- 3h 50m
- When
- Monday to Saturday
- Estimated price
- $85–500
Flights from John Glenn Columbus International Airport to Charleston International Airport via Reagan Washington
- Ave. Duration
- 4h 25m
- When
- Sunday
- Estimated price
- $110–600
Flights from John Glenn Columbus International Airport to Columbia via Charlotte
- Ave. Duration
- 4h 6m
- When
- Every day
- Estimated price
- $75–450
Flights from John Glenn Columbus International Airport to Columbia via Philadelphia
- Ave. Duration
- 5h 23m
- When
- Every day
- Estimated price
- $110–600
Flights from John Glenn Columbus International Airport to Columbia via New York La Guardia
- Ave. Duration
- 5h 40m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $130–650
Flights from John Glenn Columbus International Airport to Columbia via Reagan Washington
- Ave. Duration
- 6h 12m
- When
- Sunday
- Estimated price
- $100–550
- Website
- delta.com
Flights from John Glenn Columbus International Airport to Charleston International Airport via Atlanta
- Ave. Duration
- 3h 44m
- When
- Every day
- Estimated price
- $100–600
Flights from John Glenn Columbus International Airport to Columbia via Atlanta
- Ave. Duration
- 4h 49m
- When
- Every day
- Estimated price
- $90–500
Flights from John Glenn Columbus International Airport to Columbia via New York La Guardia
- Ave. Duration
- 5h 35m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $130–650
- Website
- united.com
Flights from John Glenn Columbus International Airport to Charleston International Airport via Washington Dulles
- Ave. Duration
- 4h 6m
- When
- Every day
- Estimated price
- $100–600
Flights from John Glenn Columbus International Airport to Columbia via Washington Dulles
- Ave. Duration
- 3h 50m
- When
- Every day
- Estimated price
- $95–550
Flights from John Glenn Columbus International Airport to Columbia via Chicago O'Hare
- Ave. Duration
- 5h 29m
- When
- Every day
- Estimated price
- $120–600
Flights from John Glenn Columbus International Airport to Columbia via Newark
- Ave. Duration
- 5h 6m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $130–650
- Website
- flybreeze.com
Flights from John Glenn Columbus International Airport to Charleston International Airport
- Ave. Duration
- 1h 43m
- When
- Thursday, Sunday, Tuesday, and Saturday
- Estimated price
- $70–500
- Website
- southwest.com
Flights from John Glenn Columbus International Airport to Charleston International Airport via Baltimore
- Ave. Duration
- 4h 6m
- When
- Saturday, Tuesday, Wednesday, and Sunday
- Estimated price
- $110–600
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Columbus - Mound St to Charlotte Bus Station
- Ave. Duration
- 10h
- Frequency
- Once daily
- Estimated price
- $40–95
- Website
- Barons Bus
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Columbus - Mound St to Charlotte Bus Station
- Ave. Duration
- 10h 55m
- Frequency
- Once daily
- Estimated price
- $65–130
- Website
- Greyhound
Bus from Charlotte Bus Station to Orangeburg
- Ave. Duration
- 4h
- Frequency
- Twice daily
- Estimated price
- $24–50
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Charlotte Bus Station to Orangeburg
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $25–45
- Schedules at
- Flixbus USA
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