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How to get fromColumbus to Santeeby plane, car, or bus (Greyhound, Flixbus)

Find Transport to Santee

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There are 4 ways to get from Columbus to Santee by plane, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charleston International Airport, drive

    best
    1. Fly from John Glenn Columbus International Airport (CMH) to Charleston International Airport (CHS)plane plane CMH - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    4h 33m
    $82–519
  2. Bus

    1. Take the bus from Columbus - Mound St to Charlotte Bus Stationbus bus Columbus
    2. Take the bus from Charlotte Bus Station to Orangeburgbus bus Greyhound US0644S / ...
    15h 28m
    $171–278
  3. Drive 573.3 mi

    1. Drive from Columbus to Santeecar car 573.3 mi
    9h 59m
    $105–152
  4. Fly to Columbia, drive

    1. Fly from John Glenn Columbus International Airport (CMH) to Columbia (CAE)plane plane CMH - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    6h 22m
    $87–469

John Glenn Columbus International Airport (CMH) to Charleston International Airport (CHS) flights

Calendar60Weekly Planes
Duration3h 32mAverage Duration
Ticket$70Cheapest Price
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Questions & Answers

What companies run services between Columbus, OH, USA and Santee, SC, USA?

You can take a bus from Columbus - Mound St to Santee via Charlotte Bus Station and Orangeburg in around 15h 28m.

Airlines
Bus operators

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