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How to get fromCosta Mesa to San Franciscoby bus, plane, bus (Greyhound), train (Amtrak), car, subway, train, or bus (Flixbus)

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There are 10 ways to get from Costa Mesa to San Francisco by bus, plane, bus (Greyhound), train (Amtrak), car, subway, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 43 bus, line 76 bus to John Wayne Airport Orange County, fly to San Francisco International Airport

    best
    1. Take the bus from Park-19Th to Harbor-Macarthurbus bus
    2. Take the bus from Macarthur-Harbor to Airport-Arrival Terminalbus bus
    3. Fly from John Wayne Airport Orange County (SNA) to San Francisco International Airport (SFO)plane plane SNA - SFO
    4h 47m
    $193–716

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Santa Ana Bus Stop to San Francisco Bus Stationbus bus Greyhound US0831
    11h 5m
    $67–132

  3. Train (Amtrak)

    1. Take the train from Santa Ana to Los Angelestrain train Pacific Surfliner
    2. Take the train from Los Angeles to Oaklandtrain train Coast Starlight
    14h 58m
    $156–339

  4. Drive 419.3 mi

    1. Drive from Costa Mesa to San Franciscocar car 419.3 mi
    7h 5m
    $77–111

  5. Line 43 bus, line 76 bus to John Wayne Airport Orange County, fly to Oakland International Airport, BART

    1. Take the bus from Park-19Th to Harbor-Macarthurbus bus
    2. Take the bus from Macarthur-Harbor to Airport-Arrival Terminalbus bus
    3. Fly from John Wayne Airport Orange County (SNA) to Oakland International Airport (OAK)plane plane SNA - OAK
    4. Take the subway from Coliseum to Powell Streetsubway subway
    4h 49m
    $249–762

  6. Line 662 bus, train to Los Angeles International Airport, fly to San Francisco International Airport

    1. Take the bus from Oc Fair-Yellow Gate to The Depot At Santa Ana Dock 9bus bus
    2. Take the train from Santa Ana to Los Angelestrain train
    3. Fly from Los Angeles International Airport (LAX) to San Francisco International Airport (SFO)plane plane LAX - SFO
    5h 51m
    $104–230

  7. Fly John Wayne Airport Orange County to Norman Y. Mineta San José International Airport, Caltrain

    1. Fly from John Wayne Airport Orange County (SNA) to Norman Y. Mineta San José International Airport (SJC)plane plane SNA - SJC
    2. Take the train from Santa Clara Caltrain Northbound to San Francisco Caltrain Northboundtrain train
    5h 56m
    $206–819

  8. Line 662 bus, train to Los Angeles International Airport, fly to Oakland International Airport, BART

    1. Take the bus from Oc Fair-Yellow Gate to The Depot At Santa Ana Dock 9bus bus
    2. Take the train from Santa Ana to Los Angelestrain train
    3. Fly from Los Angeles International Airport (LAX) to Oakland International Airport (OAK)plane plane LAX - OAK
    4. Take the subway from Coliseum to Powell Streetsubway subway
    6h 5m
    $355–1,446

  9. Line 1 bus to Long Beach Airport, fly to Oakland International Airport

    1. Take the bus from Newport Trans Ctr Dock 5 to 7Th-Channelbus bus
    2. Fly from Long Beach Airport (LGB) to Oakland International Airport (OAK)plane plane LGB - OAK
    6h 40m
    $68–366

  10. Bus via Los Angeles (Flixbus)

    1. Take the bus from Los Angeles Union Station to San Franciscobus bus FlixBus 2005
    12h 57m
    $74–133

Costa Mesa to San Francisco by bus (Greyhound)

Calendar14Weekly Buses
Duration11h 5mAverage Duration
Ticket$67Cheapest Price
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Questions & Answers

Map of how to get from Costa Mesa to San Francisco.ExpandLaunch map view
  • Distance: 396.7 mi
  • Duration: 4h 47m

What companies run services between Costa Mesa, CA, USA and San Francisco, CA, USA?

Greyhound USA operates a bus from Santa Ana Bus Stop to San Francisco Bus Station twice daily. Tickets cost $65–130 and the journey takes 9h 45m. Alternatively, you can take a bus from Oc Fair-Yellow Gate to Civic Center / UN Plaza via The Depot At Santa Ana Dock 9, Santa Ana, Los Angeles, Oakland, and Lake Merritt in around 14h 58m.

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