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How to get fromCosta Mesa to St. Louisby plane, train (Amtrak), bus (Greyhound), car, or train

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There are 10 ways to get from Costa Mesa to St. Louis by plane, train (Amtrak), bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL)plane plane SNA - STL
    8h 34m
    $207–857

  2. Train to San Diego International Airport, fly

    cheapest
    1. Take the train from Irvine to San Diego Old Town Transportation Centertrain train
    2. Fly from San Diego International Airport (SAN) to Lambert–St. Louis International Airport (STL)plane plane SAN - STL
    8h 48m
    $160–250

  3. Train via Kansas City (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Kansas Citytrain train Southwest Chief
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    43h 43m
    $642–1,392

  4. Bus

    1. Take the bus from El Monte Bus Stop to St Louis Bus Stationbus bus Greyhound US1210
    44h 47m
    $304–605

  5. Drive 1,811.8 mi

    1. Drive from Costa Mesa to St. Louiscar car 1,811.8 mi
    28h 52m
    $331–478

  6. Train to Los Angeles International Airport, fly

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Lambert–St. Louis International Airport (STL)plane plane LAX - STL
    8h 20m
    $213–401

  7. Fly from Long Beach Airport

    1. Fly from Long Beach Airport (LGB) to Lambert–St. Louis International Airport (STL)plane plane LGB - STL
    10h 29m
    $211–861

  8. Train to Burbank Bob Hope Airport, fly

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Burbank Bob Hope Airport (BUR) to Lambert–St. Louis International Airport (STL)plane plane BUR - STL
    10h 33m
    $232–738

  9. Train, train to Ontario International Airport, fly

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to Ontario Amtraktrain train
    3. Fly from Ontario International Airport (ONT) to Lambert–St. Louis International Airport (STL)plane plane ONT - STL
    11h 16m
    $240–955

  10. Train (Amtrak)

    1. Take the train from Pomona Amtrak to St. Louistrain train Texas Eagle
    2d 11h
    $755–1,610

Costa Mesa to St. Louis by bus and train (Amtrak)

Calendar7Weekly Services
Duration43h 43mAverage Duration
Ticket$642Cheapest Price
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Questions & Answers

Map of how to get from Costa Mesa to St. Louis.ExpandLaunch map view
  • Distance: 1,590.4 mi
  • Duration: 8h 34m

What companies run services between Costa Mesa, CA, USA and St. Louis, MO, USA?

Southwest Airlines, United Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Harbor-Bernard to St. Louis via Fullerton Trans Ctr Dock 2, Fullerton Amtrak Station, and Kansas City in around 43h 43m.

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