There are 4 ways to get from Cusco to Santa Cruz by plane, bus, car, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Alejandro Velasco Astete International Airport (CUZ) to Viru Viru International Airport (VVI)plane CUZ - VVI
3h 50m$287–530Bus
cheapest- Take the bus from Cusco to Terminal de Buses La Pazbus Cusco
- Take the bus from La Paz to Santa Cruzbus La Paz
32h 4m$31–398Drive 1,429.6 km
- Drive from Cusco to Santa Cruz de la Sierracar 1,429.6 km
22h 36m$215–311Bus, Tour
- Take the bus from Cusco Real Inka Car to Punobus
- Take a shuttle bus from Puno to La Paz
- Take the bus from La Paz to Cochabambabus
- Take the bus from Cochabamba to Santa Cruz de la Sierrabus
38h$255–1,182
Alejandro Velasco Astete International Airport (CUZ) to Viru Viru International Airport (VVI) flights
Comparing Your Travel Options
The cheapest way to get from Cusco to Santa Cruz is to drive which costs $210 - $310 and takes 22h 36m.
The fastest way to get from Cusco to Santa Cruz is to fly which takes 3h 50m and costs $280 - $550.
No, there is no direct bus from Cusco to Santa Cruz. However, there are services departing from Cusco and arriving at Santa Cruz via La Paz. The journey, including transfers, takes approximately 32h 4m.
The distance between Cusco and Santa Cruz is 1067 km. The road distance is 1429.6 km.
The best way to get from Cusco to Santa Cruz without a car is to bus which takes 32h 4m and costs $30 - $400.
It takes approximately 3h 50m to get from Cusco to Santa Cruz, including transfers.
Cusco to Santa Cruz bus services, operated by Nuevo Continente Internacional, depart from Cusco station.
The best way to get from Cusco to Santa Cruz is to fly which takes 3h 50m and costs $280 - $550. Alternatively, you can bus, which costs $30 - $400 and takes 32h 4m.
Cusco to Santa Cruz bus services, operated by Nuevo Continente Internacional, arrive at Terminal de Buses La Paz station.
Santa Cruz is 1h ahead of Cusco. It is currently 2:40 PM in Cusco and 3:40 PM in Santa Cruz.
What companies run services between Cusco, Peru and Santa Cruz, Bolivia?
LATAM Chile, Avianca - Aerovías del Continente Americano S.A., and two other airlines fly from Alejandro Velasco Astete International Airport (CUZ) to Viru Viru International Airport (VVI) twice daily. Alternatively, you can take a bus from Cusco to Santa Cruz de la Sierra via La Paz and Santa Cruz in around 32h 4m.
- Website
- boa.bo
Flights from Alejandro Velasco Astete International Airport to Viru Viru International Airport via La Paz
- Ave. Duration
- 3h 15m
- When
- Every day
- Estimated price
- $320–600
Flights from Alejandro Velasco Astete International Airport to Viru Viru International Airport via Lima
- Ave. Duration
- 5h
- When
- Friday
- Estimated price
- $320–600
- Phone
- +591 2228 3843
- [email protected]
- Website
- facebook.com
Bus from Cusco to Terminal de Buses La Paz
- Ave. Duration
- 13h
- Frequency
- Once daily
- Estimated price
- $21–350
- Book at
- Tickets Bolivia
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Booking & Getting There
Yes, the driving distance between Cusco to Santa Cruz is 1430 km. It takes approximately 22h 36m to drive from Cusco to Santa Cruz.
There are 754+ hotels available in Santa Cruz.