There are 4 ways to get from Cusco to Santa Cruz by plane, bus, car, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Alejandro Velasco Astete International Airport (CUZ) to Viru Viru International Airport (VVI)plane CUZ - VVI
4h 50m$287–536Bus
cheapest- Take the bus from Cusco to Terminal de Buses La Pazbus Cusco
- Take the bus from La Paz to Santa Cruzbus La Paz
32h 4m$29–409Drive 1,429.4 km
- Drive from Cusco to Santa Cruz de la Sierracar 1,429.4 km
22h 36m$215–311Bus, Tour
- Take the bus from Cusco Real Inka Car to Punobus
- Take a shuttle bus from Puno to La Paz
- Take the bus from La Paz to Cochabambabus
- Take the bus from Cochabamba to Santa Cruz de la Sierrabus
38h$254–1,182
Alejandro Velasco Astete International Airport (CUZ) to Viru Viru International Airport (VVI) flights
Questions & Answers
The cheapest way to get from Cusco to Santa Cruz is to drive which costs $210 - $310 and takes 22h 36m.
The fastest way to get from Cusco to Santa Cruz is to fly which takes 4h 50m and costs $280 - $550.
No, there is no direct bus from Cusco to Santa Cruz. However, there are services departing from Cusco and arriving at Santa Cruz via La Paz. The journey, including transfers, takes approximately 32h 4m.
The distance between Cusco and Santa Cruz is 1067 km. The road distance is 1429.4 km.
The best way to get from Cusco to Santa Cruz without a car is to bus which takes 32h 4m and costs $29 - $410.
It takes approximately 4h 50m to get from Cusco to Santa Cruz, including transfers.
Cusco to Santa Cruz bus services, operated by Nuevo Continente Internacional, depart from Cusco station.
The best way to get from Cusco to Santa Cruz is to fly which takes 4h 50m and costs $280 - $550. Alternatively, you can bus, which costs $29 - $410 and takes 32h 4m.
Cusco to Santa Cruz bus services, operated by Nuevo Continente Internacional, arrive at Terminal de Buses La Paz station.
Santa Cruz is 1h ahead of Cusco. It is currently 7:54 PM in Cusco and 8:54 PM in Santa Cruz.
What companies run services between Cusco, Peru and Santa Cruz, Bolivia?
LATAM Chile, Avianca - Aerovías del Continente Americano S.A., and two other airlines fly from Alejandro Velasco Astete International Airport (CUZ) to Viru Viru International Airport (VVI) twice daily. Alternatively, you can take a bus from Cusco to Santa Cruz de la Sierra via La Paz and Santa Cruz in around 32h 4m.
- Website
- boa.bo
Flights from Alejandro Velasco Astete International Airport to Viru Viru International Airport via La Paz
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $300–600
Flights from Alejandro Velasco Astete International Airport to Viru Viru International Airport via Lima
- Ave. Duration
- 5h
- When
- Monday and Friday
- Estimated price
- $300–600
- Website
- latam.com
Flights from Alejandro Velasco Astete International Airport to Viru Viru International Airport via Lima
- Ave. Duration
- 5h 25m
- When
- Wednesday and Thursday
- Estimated price
- $280–550
- Phone
- +591 22283843
- [email protected]
- Website
- facebook.com
Bus from Cusco to Terminal de Buses La Paz
- Ave. Duration
- 13h
- Frequency
- Once daily
- Estimated price
- $20–350
- Book at
- https://www.ticketsbolivia.com/company/nc_internacional.php
- Phone
- +591-72233555
- [email protected]
- Website
- transcopacabanasa.com
Bus from La Paz to Santa Cruz
- Ave. Duration
- 18h
- Frequency
- 4 times a day
- Estimated price
- $18–24
- Schedules at
- transcopacabanasa.com
- Phone
- +591 7297 1111
- Website
- facebook.com
Bus from La Paz to Santa Cruz
- Ave. Duration
- 14h
- Frequency
- Once daily
- Estimated price
- $35–55
- Schedules at
- facebook.com
- Phone
- +591 69414917
- Website
- facebook.com
Bus from La Paz to Santa Cruz
- Ave. Duration
- 16h 20m
- Frequency
- Once daily
- Estimated price
- $7–19
- Schedules at
- facebook.com
- Normal
- $7–10
- Semicama
- $10–14
- Cama
- $16–19
- Phone
- +591 69416892
- [email protected]
- Website
- facebook.com
Bus from La Paz to Santa Cruz
- Ave. Duration
- 18h
- Frequency
- Once daily
- Estimated price
- $9–13
- Schedules at
- facebook.com
- Phone
- +59176400493
- Website
- flotaeldorado.com
Bus from La Paz to Santa Cruz
- Ave. Duration
- 18h
- Frequency
- Once daily
- Estimated price
- $18–65
- Schedules at
- flotaeldorado.com
- Book at
- flotaeldorado.com
- Phone
- +51993063390
- [email protected]
- Website
- realinkacar.com
Bus from Cusco Real Inka Car to Puno
- Ave. Duration
- 9h 25m
- Frequency
- On demand
- Estimated price
- $190–1,200
- Schedules at
- realinkacar.com
- Book at
- realinkacar.com
- Phone
- +51 051 630 257
- [email protected]
- Website
- titicaca.cruises
Shuttle from Puno to La Paz
- Ave. Duration
- 12h 30m
- Frequency
- Hourly
- Estimated price
- $50
- Schedules at
- titicaca.cruises
- Phone
- +59176401000
- Website
- facebook.com
Bus from La Paz to Cochabamba
- Ave. Duration
- 7h 45m
- Frequency
- 5 times a day
- Estimated price
- $9
- Book at
- ticketsbolivia.com.bo
- Phone
- +591 72201573
- [email protected]
- Website
- facebook.com
Bus from Cochabamba to Santa Cruz de la Sierra
- Ave. Duration
- 6h
- Frequency
- Hourly
- Estimated price
- $2
- Website
- https://www.facebook.com/p/Minibuses-Carrasco-Tropical-100089251686191/
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More Questions & Answers
Yes, the driving distance between Cusco to Santa Cruz is 1429 km. It takes approximately 22h 36m to drive from Cusco to Santa Cruz.
There are 740+ hotels available in Santa Cruz.



















