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How to get fromCusco to Santa Cruzby plane, train, bus, or car

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There are 5 ways to get from Cusco to Santa Cruz by plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, train, bus

    best
    1. Fly from Alejandro Velasco Astete International Airport (CUZ) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane CUZ - SCL
    2. Take the train from Estacion Central Alameda to San Fernandotrain train
    3. Take the bus from Terminal Rodoviario de San Fernando to Terminal de Buses Santa Cruzbus bus
    7h 46m
    $148–338

  2. Bus via Oruro Airport (ORU)

    cheapest
    1. Take the bus from Cusco to Terminal de Buses La Pazbus bus
    2. Take the bus from La Paz to Orurobus bus
    3. Take the bus from Oruro to Terminal Alameda - Turbusbus bus
    4. Take the bus from Terminal Sur de Santiago to Terminal de Buses Santa Cruzbus bus
    2d 8h
    $81–420

  3. Bus via Arequipa

    1. Take the bus from Cusco to Arequipabus bus
    2. Take the bus from Arequipa to Tacnabus bus
    3. Take the bus from Terminal Terrestre Internacional Manuel A. Odría to Terminal Internacional Aricabus bus
    4. Take the bus from Terminal Rodoviario de Arica to Terminal San Borjabus bus
    5. Take the bus from Terminal Sur de Santiago to Hospitalbus bus
    46h 26m

  4. Drive 3,006.7 km

    1. Drive from Cusco to Santa Cruzcar car 3,006.7 km
    40h 8m
    $452–653

  5. Bus

    1. Take the bus from Cusco Bus Station to Tacna Bus Stationbus bus
    2. Take the bus from Terminal Terrestre Internacional Manuel A. Odría to Terminal Internacional Aricabus bus
    3. Take the bus from Terminal Rodoviario de Arica to Terminal San Borjabus bus
    4. Take the bus from Terminal Sur de Santiago to Terminal de Buses Santa Cruzbus bus
    2d 5h
    $94–213

Alejandro Velasco Astete International Airport (CUZ) to Comodoro Arturo Merino Benítez International Airport (SCL) flights

Calendar69Weekly Planes
Duration6h 4mAverage Duration
Ticket$133Cheapest Price
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Questions & Answers

Map of how to get from Cusco to Santa Cruz.ExpandLaunch map view
  • Distance: 2,405.3 km
  • Duration: 7h 46m

What companies run services between Cusco, Peru and Santa Cruz, O'Higgins, Chile?

You can take a bus from Cusco to Hospital via Arequipa, Tacna, Terminal Terrestre Internacional Manuel A. Odría, Terminal Internacional Arica, Terminal Rodoviario de Arica, Terminal San Borja, and Terminal Sur de Santiago in around 46h 26m.

Airlines
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