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How to get fromCusco to Santiagoby plane, bus, or car

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There are 5 ways to get from Cusco to Santiago by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Alejandro Velasco Astete International Airport (CUZ) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane CUZ - SCL
    3h 42m
    $134–323

  2. Bus via Oruro Airport (ORU)

    cheapest
    1. Take the bus from Cusco to Terminal de Buses La Pazbus bus
    2. Take the bus from La Paz to Orurobus bus
    3. Take the bus from Oruro to Terminal Alameda - Turbusbus bus
    2d 5h
    $82–411

  3. Bus via Arequipa

    1. Take the bus from Cusco to Arequipabus bus
    2. Take the bus from Arequipa to Tacnabus bus
    3. Take the bus from Terminal Terrestre Internacional Manuel A. Odría to Terminal Internacional Aricabus bus
    4. Take the bus from Terminal Rodoviario de Arica to Terminal San Borjabus bus
    43h 5m

  4. Drive  2,879.3 km

    1. Drive from Cusco to Santiagocar car 2,879.3 km
    38h 46m
    $433–626

  5. Bus

    1. Take the bus from Cusco Bus Station to Tacna Bus Stationbus bus
    2. Take the bus from Terminal Terrestre Internacional Manuel A. Odría to Terminal Internacional Aricabus bus
    3. Take the bus from Terminal Rodoviario de Arica to Terminal San Borjabus bus
    2d 1h
    $90–200

Alejandro Velasco Astete International Airport (CUZ) to Comodoro Arturo Merino Benítez International Airport (SCL) flights

Calendar60Weekly Planes
Duration6h 6mAverage Duration
Ticket$115Cheapest Price
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Questions & Answers

Map of how to get from Cusco to Santiago.ExpandLaunch map view
  • Distance: 2,223.6 km
  • Duration: 3h 42m

What companies run services between Cusco, Peru and Santiago, Chile?

LATAM Chile, JetSMART, and Sky Airline fly from Alejandro Velasco Astete International Airport (CUZ) to Comodoro Arturo Merino Benítez International Airport (SCL) every 3 hours. Alternatively, you can take a bus from Cusco to Terminal San Borja via Arequipa, Tacna, Terminal Terrestre Internacional Manuel A. Odría, Terminal Internacional Arica, and Terminal Rodoviario de Arica in around 43h 5m.

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