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How to get fromCusco to Santiagoby plane, bus, or car

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There are 5 ways to get from Cusco to Santiago by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Alejandro Velasco Astete International Airport (CUZ) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane CUZ - SCL
    3h 42m
    $132–311

  2. Bus via Oruro Airport (ORU)

    cheapest
    1. Take the bus from Cusco to Terminal de Buses La Pazbus bus
    2. Take the bus from La Paz to Orurobus bus
    3. Take the bus from Oruro to Terminal Alameda - Turbusbus bus
    2d 5h
    $77–408

  3. Bus via Arequipa

    1. Take the bus from Cusco to Arequipabus bus
    2. Take the bus from Arequipa to Tacnabus bus
    3. Take the bus from Terminal Terrestre Internacional Manuel A. Odría to Terminal Internacional Aricabus bus
    4. Take the bus from Terminal Rodoviario de Arica to Terminal San Borjabus bus
    43h 5m

  4. Drive  2,879.3 km

    1. Drive from Cusco to Santiagocar car 2,879.3 km
    38h 46m
    $433–626

  5. Bus

    1. Take the bus from Cusco Bus Station to Tacna Bus Stationbus bus
    2. Take the bus from Terminal Terrestre Internacional Manuel A. Odría to Terminal Internacional Aricabus bus
    3. Take the bus from Terminal Rodoviario de Arica to Terminal San Borjabus bus
    2d 1h
    $84–190

Alejandro Velasco Astete International Airport (CUZ) to Comodoro Arturo Merino Benítez International Airport (SCL) flights

Calendar68Weekly Planes
Duration5h 55mAverage Duration
Ticket$113Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cusco to Santiago.ExpandLaunch map view
  • Distance: 2,223.6 km
  • Duration: 3h 42m

What companies run services between Cusco, Peru and Santiago, Chile?

Sky Airline, LATAM Chile, and JetSMART fly from Alejandro Velasco Astete International Airport (CUZ) to Comodoro Arturo Merino Benítez International Airport (SCL) every 3 hours. Alternatively, you can take a bus from Cusco to Terminal San Borja via Arequipa, Tacna, Terminal Terrestre Internacional Manuel A. Odría, Terminal Internacional Arica, and Terminal Rodoviario de Arica in around 43h 5m.

Airlines
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Want to know more about travelling around the world?

Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Which London airport should I choose?, Need to know: Greyhound, and What are the different types of Renfe trains in Spain? - to help you get the most out of your next trip.

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