There are 7 ways to get from De Soto to Chicago by plane, train (Amtrak), bus, car, taxi, or bus (Flixbus, Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Williamson County Regional Airport
best- Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane MWA - ORD
2h 50m$127–278Drive to Barkley Regional Airport, fly
cheapest- Drive from De Soto to Barkley Regional Airport (PAH)car
- Fly from Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD)plane PAH - ORD
3h 38m$55–284Train (Amtrak)
- Take the train from Carbondale to Chicago Union Stationtrain Saluki / ...
5h 40m$112–230Bus
- Take the bus from Marathon Gas Station - Marion to Chicagobus Querétaro / ...
6h 41m$115–238Drive 324.6 mi
- Drive from De Soto to Chicagocar 324.6 mi
5h 34m$60–86Taxi to Cape Girardeau Municipal Airport, fly
- Take the taxi from De Soto to Cape Girardeau Municipal Airport (CGI)taxi
- Fly from Cape Girardeau Municipal Airport (CGI) to Chicago O'Hare International Airport (ORD)plane CGI - ORD
3h 49m$232–384Bus via St. Louis
- Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus FlixBus N2521
- Take the bus from St Louis Bus Station to Chicago Bus Stationbus FlixBus N2521 / ...
9h 10m$82–150
Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) flights
Questions & Answers
The cheapest way to get from De Soto to Chicago is to drive which costs $55 - $90 and takes 5h 34m.
The fastest way to get from De Soto to Chicago is to fly which takes 2h 50m and costs $120 - $280.
No, there is no direct bus from De Soto station to Chicago. However, there are services departing from Marathon Gas Station - Marion and arriving at Dearborn & Harrison via California & 35th Street and 35th/Archer Orange Line Station. The journey, including transfers, takes approximately 6h 41m.
No, there is no direct train from De Soto to Chicago station. However, there are services departing from Carbondale and arriving at Chicago Union Station via . The journey, including transfers, takes approximately 5h 40m.
The distance between De Soto and Chicago is 335 miles. The road distance is 326.5 miles.
The best way to get from De Soto to Chicago without a car is to train which takes 5h 40m and costs $110 - $230.
It takes approximately 2h 50m to get from De Soto to Chicago, including transfers.
De Soto to Chicago bus services, operated by Tornado Bus Company, depart from Marathon Gas Station - Marion.
De Soto to Chicago train services, operated by Amtrak, depart from Carbondale station.
The best way to get from De Soto to Chicago is to fly which takes 2h 50m and costs $120 - $280. Alternatively, you can train, which costs $110 - $230 and takes 5h 40m, you could also bus, which costs $110 - $240 and takes 6h 41m.
What companies run services between De Soto, IL, USA and Chicago, IL, USA?
Corporate Flight Management Inc and American Airlines fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) 3 times a day. Alternatively, Amtrak operates a train from Carbondale to Chicago Union Station 3 times a day. Tickets cost $95–210 and the journey takes 5h 30m.
- Website
- contouraviation.com
Flights from Williamson County Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $80–220
Flights from Cape Girardeau Municipal Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 45m
- When
- Every day
- Estimated price
- $95–220
- Website
- aa.com
Flights from Williamson County Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 44m
- When
- Every day
- Estimated price
- $45–290
- Website
- united.com
Flights from Barkley Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 28m
- When
- Every day
- Estimated price
- $40–260
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Carbondale to Chicago Union Station
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $95–210
- Website
- Amtrak
- Phone
- +1 888 358 6762
- [email protected]
- Website
- Tornado Bus Company
Bus from Marathon Gas Station - Marion to Chicago
- Ave. Duration
- 5h 25m
- Frequency
- Once daily
- Estimated price
- $65–180
- Schedules at
- Tornado Bus Company
- Adults 11-59
- $65–180
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Carbondale Intermodal Station to St Louis Bus Station
- Ave. Duration
- 1h 55m
- Frequency
- Once daily
- Estimated price
- $15–26
- Schedules at
- Flixbus USA
Bus from St Louis Bus Station to Chicago Bus Station
- Ave. Duration
- 6h 5m
- Frequency
- 4 times a day
- Estimated price
- $50–85
- Schedules at
- Flixbus USA
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Carbondale Intermodal Station to St Louis Bus Station
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–45
- Website
- Amtrak
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More Questions & Answers
De Soto to Chicago bus services, operated by Tornado Bus Company, arrive at Chicago station.
De Soto to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between De Soto to Chicago is 326 miles. It takes approximately 5h 34m to drive from De Soto to Chicago.
There are 1149+ hotels available in Chicago.