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How to get fromDeSoto to St. Louisby bus, plane, bus (Flixbus, Greyhound), train (Amtrak), or car

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There are 5 ways to get from DeSoto to St. Louis by bus, plane, bus (Flixbus, Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 306 bus to Dallas, fly

    best
    1. Take the bus from Glenn Heights P & R to Southwest Medical District/Parklandbus bus
    2. Fly from Dallas (DAL) to Lambert–St. Louis International Airport (STL)plane plane DAL - STL
    4h 35m
    $107–562

  2. Bus

    1. Take the bus from Downtown Dallas / Deep Ellum to Oklahoma City Bus Stationbus bus FlixBus 2242
    2. Take the bus from Oklahoma City Bus Station to St Louis Bus Stationbus bus Greyhound US1210
    16h 55m
    $116–211

  3. Train (Amtrak)

    1. Take the train from Dallas to St. Louistrain train Texas Eagle
    17h 55m
    $234–474

  4. Drive 643.9 mi

    1. Drive from DeSoto to St. Louiscar car 643.9 mi
    10h 47m
    $118–170

  5. Line 306 bus to Dallas/Fort Worth International Airport, fly

    1. Take the bus from Glenn Heights P & R to Southwest Medical District/Parklandbus bus
    2. Fly from Dallas/Fort Worth International Airport (DFW) to Lambert–St. Louis International Airport (STL)plane plane DFW - STL
    5h 38m
    $349–609

DeSoto to St. Louis by bus

Calendar5Weekly Buses
Duration16h 55mAverage Duration
Ticket$116Cheapest Price
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Questions & Answers

Map of how to get from DeSoto to St. Louis.ExpandLaunch map view
  • Distance: 583.3 mi
  • Duration: 4h 35m

What companies run services between DeSoto, TX, USA and St. Louis, MO, USA?

You can take a bus from Glenn Heights P & R to St Louis Bus Station via Southwest Medical District/Parkland, Gaston @ Good Latimer - N - Ns, Downtown Dallas / Deep Ellum, and Oklahoma City Bus Station in around 16h 55m. Alternatively, Amtrak operates a train from Dallas to St. Louis once daily. Tickets cost $230–470 and the journey takes 15h 47m.

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