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How to get fromDenver Airport (DEN) to Knoxvilleby plane, train, bus, bus (Greyhound, Flixbus), or car

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There are 8 ways to get from Denver Airport (DEN) to Knoxville by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Denver (DEN) to Mcghee Tyson Airport (TYS)plane plane DEN - TYS
    3h 2m
    $258–1,006

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Denver (DEN) to Asheville Regional Airport (AVL)plane plane DEN - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    5h 8m
    $131–532

  3. Train, bus

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    2d 7h
    $813–1,613

  4. Bus

    1. Take the bus from Denver Union Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 12h
    $409–675

  5. Drive 1,307 mi

    1. Drive from Denver Airport (DEN) to Knoxvillecar car 1,307 mi
    21h 38m
    $239–345

  6. Fly to Nashville, drive

    1. Fly from Denver (DEN) to Nashville (BNA)plane plane DEN - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 19m
    $210–604

  7. Fly to Blue Grass Airport, drive

    1. Fly from Denver (DEN) to Blue Grass Airport (LEX)plane plane DEN - LEX
    2. Drive from Lexington-Airport-LEX to Knoxvillecar car
    5h 46m
    $241–1,042

  8. Train, bus via Ossining

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 7h
    $768–1,540

Denver (DEN) to Mcghee Tyson Airport (TYS) flights

Calendar56Weekly Planes
Duration4h 19mAverage Duration
Ticket$202Cheapest Price
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Questions & Answers

Map of how to get from Denver Airport (DEN) to Knoxville.ExpandLaunch map view
  • Distance: 1,172.7 mi
  • Duration: 3h 2m

What companies run services between Denver Airport (DEN), USA and Knoxville, TN, USA?

Allegiant Air, United Airlines, and two other airlines fly from Denver (DEN) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a train from Denver Airport Station to Knoxville Station Hall of Fame via Union Station, Denver Union Station, Chicago Bus Station, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 2d 12h.

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