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How to get fromDenver Airport (DEN) to La Crosseby plane, bus (Greyhound), train (Amtrak), car, train, or bus

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There are 9 ways to get from Denver Airport (DEN) to La Crosse by plane, bus (Greyhound), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to La Crosse

    best
    1. Fly from Denver (DEN) to La Crosse (LSE)plane plane DEN - LSE
    5h 23m
    $119–490

  2. Fly to Rochester, bus

    cheapest
    1. Fly from Denver (DEN) to Rochester (RST)plane plane DEN - RST
    2. Take the bus from Rochester to La Crossebus bus
    7h 46m
    $106–476

  3. Bus

    1. Take the bus from Denver Airport Station Gate 8 to US 36 & Flatiron Station Gate Abus bus Ab1 / ...
    2. Take the bus from Denver Union Station to Des Moinesbus bus
    3. Take the bus from Des Moines to Saint Paul Union Depotbus bus
    4. Take the bus from St. Paul to La Crossebus bus
    26h 14m
    $181–341

  4. Train (Amtrak)

    1. Take the train from Denver to Chicago Union Stationtrain train California Zephyr
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    26h 16m
    $415–900

  5. Drive 887.3 mi

    1. Drive from Denver Airport (DEN) to La Crossecar car 887.3 mi
    15h 9m
    $162–234

  6. Fly to Minneapolis–Saint Paul International Airport, train

    1. Fly from Denver (DEN) to Minneapolis–Saint Paul International Airport (MSP)plane plane DEN - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    6h 23m
    $136–416

  7. Fly to Dane County Regional Airport-Truax Field, bus

    1. Fly from Denver (DEN) to Dane County Regional Airport-Truax Field (MSN)plane plane DEN - MSN
    2. Take the bus from Madison to La Crossebus bus
    6h 33m
    $163–689

  8. Fly to Appleton International Airport, bus

    1. Fly from Denver (DEN) to Appleton International Airport (ATW)plane plane DEN - ATW
    2. Take the bus from Appleton Valley Transit to La Crosse Grand River Stationbus bus
    7h 44m
    $211–855

  9. Bus via Sioux Falls

    1. Take the bus from Denver to Omaha, NEbus bus
    2. Take the bus from Omaha to Sioux Fallsbus bus
    3. Take the bus from Sioux Falls to Minneapolisbus bus
    4. Take the bus from Minneapolis to La Crossebus bus
    27h 42m
    $320–425

Denver Airport (DEN) to La Crosse by bus

Calendar7Weekly Buses
Duration26h 14mAverage Duration
Ticket$181Cheapest Price
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Questions & Answers

Map of how to get from Denver Airport (DEN) to La Crosse.ExpandLaunch map view
  • Distance: 750.4 mi
  • Duration: 5h 23m

What companies run services between Denver Airport (DEN), USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Denver (DEN) to La Crosse (LSE) 4 times a day. Alternatively, you can take a bus from Denver Airport Station Gate 8 to La Crosse via US 36 & Flatiron Station Gate A, US 36 & Flatiron Station Gate D, Union Station, Denver Union Station, Des Moines, and St. Paul in around 26h 14m.

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