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How to get fromDenver to Knoxvilleby plane, train, bus, bus (Greyhound, Flixbus), or car

Find Transport to Knoxville

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There are 7 ways to get from Denver to Knoxville by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Denver (DEN) to Mcghee Tyson Airport (TYS)plane plane DEN - TYS
    4h 42m
    $270–1,098

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Denver (DEN) to Asheville Regional Airport (AVL)plane plane DEN - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 43m
    $122–505

  3. Train, bus

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    2d 5h
    $1,251–1,974

  4. Bus

    1. Take the bus from Denver Union Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    2d 7h
    $489–739

  5. Drive  1,313.7 mi

    1. Drive from Denver to Knoxvillecar car 1,313.7 mi
    21h 47m
    $240–347

  6. Fly to Nashville, drive

    1. Fly from Denver (DEN) to Nashville (BNA)plane plane DEN - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 54m
    $210–552

  7. Train, bus via Ossining

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 6h
    $1,216–1,851

Denver (DEN) to Mcghee Tyson Airport (TYS) flights

Calendar58Weekly Planes
Duration3h 55mAverage Duration
Ticket$214Cheapest Price
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Comparing Your Travel Options

Map of how to get from Denver to Knoxville.ExpandLaunch map view
  • Distance: 1,196.1 mi
  • Duration: 4h 42m

What companies run services between Denver, CO, USA and Knoxville, TN, USA?

Allegiant Air, United Airlines, and two other airlines fly from Denver (DEN) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a bus from Denver Union Station to Knoxville via Chicago Bus Station, New York Midtown, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 2d 7h.

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