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How to get fromDenver to La Crosseby plane, bus (Greyhound), train (Amtrak), car, train, or bus

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There are 9 ways to get from Denver to La Crosse by plane, bus (Greyhound), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to La Crosse

    best
    1. Fly from Denver (DEN) to La Crosse (LSE)plane plane DEN - LSE
    7h 3m
    $124–493

  2. Fly to Rochester, bus

    cheapest
    1. Fly from Denver (DEN) to Rochester (RST)plane plane DEN - RST
    2. Take the bus from Rochester to La Crossebus bus
    9h 21m
    $114–480

  3. Bus

    1. Take the bus from Denver Union Station to Des Moinesbus bus
    2. Take the bus from Des Moines to Saint Paul Union Depotbus bus
    3. Take the bus from St. Paul to La Crossebus bus
    23h 56m
    $167–310

  4. Train (Amtrak)

    1. Take the train from Denver to Chicago Union Stationtrain train California Zephyr
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    24h 39m
    $355–783

  5. Drive 893.1 mi

    1. Drive from Denver to La Crossecar car 893.1 mi
    15h 16m
    $163–236

  6. Fly to Minneapolis–Saint Paul International Airport, train

    1. Fly from Denver (DEN) to Minneapolis–Saint Paul International Airport (MSP)plane plane DEN - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    8h 3m
    $137–423

  7. Fly to Dane County Regional Airport-Truax Field, bus

    1. Fly from Denver (DEN) to Dane County Regional Airport-Truax Field (MSN)plane plane DEN - MSN
    2. Take the bus from Madison to La Crossebus bus
    8h 9m
    $217–667

  8. Fly to Appleton International Airport, bus

    1. Fly from Denver (DEN) to Appleton International Airport (ATW)plane plane DEN - ATW
    2. Take the bus from Appleton Valley Transit to La Crosse Grand River Stationbus bus
    9h 24m
    $140–488

  9. Bus via Sioux Falls

    1. Take the bus from Denver to Omaha, NEbus bus
    2. Take the bus from Omaha to Sioux Fallsbus bus
    3. Take the bus from Sioux Falls to Minneapolisbus bus
    4. Take the bus from Minneapolis to La Crossebus bus
    26h 5m
    $310–414

Denver to La Crosse by bus

Calendar7Weekly Buses
Duration23h 56mAverage Duration
Ticket$167Cheapest Price
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Questions & Answers

Map of how to get from Denver to La Crosse.ExpandLaunch map view
  • Distance: 773.7 mi
  • Duration: 7h 3m

What companies run services between Denver, CO, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Denver (DEN) to La Crosse (LSE) 4 times a day. Alternatively, you can take a bus from Denver Union Station to La Crosse via Des Moines and St. Paul in around 23h 56m.

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