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How to get fromDenver to La Crosseby plane, bus (Greyhound), train (Amtrak), car, train, or bus

Find Transport to La Crosse

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There are 8 ways to get from Denver to La Crosse by plane, bus (Greyhound), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to La Crosse

    best
    1. Fly from Denver (DEN) to La Crosse (LSE)plane plane DEN - LSE
    6h 47m
    $111–466

  2. Fly to Rochester, bus

    cheapest
    1. Fly from Denver (DEN) to Rochester (RST)plane plane DEN - RST
    2. Take the bus from Rochester to La Crossebus bus
    9h 27m
    $101–461

  3. Bus

    1. Take the bus from Denver Union Station to Des Moinesbus bus
    2. Take the bus from Des Moines to Minneapolis Bus Stationbus bus
    3. Take the bus from Minneapolis to La Crossebus bus
    23h 35m
    $197–304

  4. Train (Amtrak)

    1. Take the train from Denver to Chicago Union Stationtrain train California Zephyr
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    24h 39m
    $721–1,116

  5. Drive  893.1 mi

    1. Drive from Denver to La Crossecar car 893.1 mi
    15h 16m
    $163–236

  6. Fly to Minneapolis–Saint Paul International Airport, train

    1. Fly from Denver (DEN) to Minneapolis–Saint Paul International Airport (MSP)plane plane DEN - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    8h 3m
    $166–441

  7. Fly to Dane County Regional Airport-Truax Field, bus

    1. Fly from Denver (DEN) to Dane County Regional Airport-Truax Field (MSN)plane plane DEN - MSN
    2. Take the bus from Madison to La Crossebus bus
    8h 14m
    $152–655

  8. Bus via Sioux Falls

    1. Take the bus from Denver to Omahabus bus
    2. Take the bus from Omaha to Sioux Fallsbus bus
    3. Take the bus from Sioux Falls to Minneapolisbus bus
    4. Take the bus from Minneapolis to La Crossebus bus
    26h 5m
    $310–414

Denver to La Crosse by bus

Calendar7Weekly Buses
Duration23h 35mAverage Duration
Ticket$197Cheapest Price
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Comparing Your Travel Options

Map of how to get from Denver to La Crosse.ExpandLaunch map view
  • Distance: 773.7 mi
  • Duration: 6h 47m

What companies run services between Denver, CO, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Denver (DEN) to La Crosse (LSE) 4 times a day. Alternatively, you can take a bus from Denver Union Station to La Crosse via Des Moines and Minneapolis in around 23h 35m.

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Need to know: Greyhound

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