Rome2Rio

How to get fromDenver to Mayo Clinicby plane, bus (Greyhound), train, bus, or car

Find Transport to Mayo Clinic

See all options

There are 7 ways to get from Denver to Mayo Clinic by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Denver (DEN) to Rochester (RST)plane plane DEN - RST
    6h 33m
    $86–440

  2. Bus

    1. Take the bus from Denver Union Station to Des Moinesbus bus
    2. Take the bus from Des Moines to Saint Paul Union Depotbus bus
    3. Take the bus from St. Paul to Rochesterbus bus
    22h 9m
    $155–285

  3. Train, bus

    1. Take the train from Denver to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    28h 26m
    $355–743

  4. Drive 830.8 mi

    1. Drive from Denver to Mayo Cliniccar car 830.8 mi
    14h 15m
    $152–219

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Denver (DEN) to Minneapolis–Saint Paul International Airport (MSP)plane plane DEN - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 28m
    $152–392

  6. Fly to Fort Dodge Municipal Airport, drive

    1. Fly from Denver (DEN) to Fort Dodge Municipal Airport (FOD)plane plane DEN - FOD
    2. Drive from Fort Dodge Municipal Airport (FOD) to Mayo Cliniccar car
    6h 56m
    $100–420

  7. Bus via Sioux Falls

    1. Take the bus from Denver to Omaha, NEbus bus
    2. Take the bus from Omaha to Sioux Fallsbus bus
    3. Take the bus from Sioux Falls to Minneapolis-St. Paulbus bus
    4. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    26h 32m
    $325–414

Denver to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration22h 9mAverage Duration
Ticket$155Cheapest Price
See schedules

Questions & Answers

Map of how to get from Denver to Mayo Clinic.ExpandLaunch map view
  • Distance: 718.5 mi
  • Duration: 6h 33m

What companies run services between Denver, CO, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and two other airlines fly from Denver (DEN) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from Denver Union Station to Mayo Clinic via Des Moines, St. Paul, and Rochester in around 22h 9m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers