There are 5 ways to get from Denver to Murphysboro by plane, bus, bus (Greyhound, Amtrak, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Lambert–St. Louis International Airport, bus
best- Fly from Denver (DEN) to Lambert–St. Louis International Airport (STL)plane DEN - STL
- Take the bus from St. Louis to Carbondalebus
7h 34m$226–581Fly to Williamson County Regional Airport
cheapest- Fly from Denver (DEN) to Williamson County Regional Airport (MWA)plane DEN - MWA
7h 46m$155–570Bus
- Take the bus from Denver Union Station to St Louis Bus Stationbus Greyhound US1200 / ...
- Take the bus from St. Louis to Carbondalebus Amtrak Thruway Connecting Service
19h 40m$161–310Drive 929.6 mi
- Drive from Denver to Murphysborocar 929.6 mi
15h 16m$170–246Fly to Nashville, bus
- Fly from Denver (DEN) to Nashville (BNA)plane DEN - BNA
- Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus
9h 55m$241–685
Denver (DEN) to Lambert–St. Louis International Airport (STL) flights
Questions & Answers
The cheapest way to get from Denver to Murphysboro is to bus which costs $160 - $310 and takes 19h 40m.
The fastest way to get from Denver to Murphysboro is to fly and bus which takes 7h 34m and costs $220 - $600.
No, there is no direct bus from Denver station to Murphysboro. However, there are services departing from Denver Union Station and arriving at Carbondale via St. Louis. The journey, including transfers, takes approximately 19h 40m.
The distance between Denver and Murphysboro is 914 miles. The road distance is 935 miles.
The best way to get from Denver to Murphysboro without a car is to bus which takes 19h 40m and costs $160 - $310.
It takes approximately 7h 34m to get from Denver to Murphysboro, including transfers.
Denver to Murphysboro bus services, operated by Greyhound USA, depart from Denver Union Station.
The best way to get from Denver to Murphysboro is to bus which takes 19h 40m and costs $160 - $310. Alternatively, you can fly, which costs $150 - $600 and takes 7h 46m.
Denver to Murphysboro bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Murphysboro is 1h ahead of Denver. It is currently 2:49 PM in Denver and 3:49 PM in Murphysboro.
What companies run services between Denver, CO, USA and Murphysboro, IL, USA?
You can take a bus from Denver Union Station to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 19h 40m. Alternatively, United Airlines, Corporate Flight Management Inc, and two other airlines fly from Denver (DEN) to Williamson County Regional Airport (MWA) 5 times a day.
- Website
- southwest.com
Flights from Denver to Lambert–St. Louis International Airport
- Ave. Duration
- 2h 2m
- When
- Every day
- Estimated price
- $110–600
Flights from Denver to Nashville
- Ave. Duration
- 2h 31m
- When
- Every day
- Estimated price
- $100–500
Flights from Denver to Nashville via Omaha
- Ave. Duration
- 4h 5m
- When
- Monday, Thursday, and Friday
- Estimated price
- $100–550
Flights from Denver to Nashville via Lambert–St. Louis International Airport
- Ave. Duration
- 4h 15m
- When
- Sunday
- Estimated price
- $100–550
Flights from Denver to Nashville via Kansas City
- Ave. Duration
- 4h 15m
- When
- Monday, Thursday, and Friday
- Estimated price
- $100–500
Flights from Denver to Nashville via Tulsa
- Ave. Duration
- 4h 20m
- When
- Tuesday, Wednesday, and Sunday
- Estimated price
- $100–550
- Website
- united.com
Flights from Denver to Lambert–St. Louis International Airport
- Ave. Duration
- 2h 9m
- When
- Every day
- Estimated price
- $110–600
Flights from Denver to Nashville
- Ave. Duration
- 2h 41m
- When
- Every day
- Estimated price
- $100–500
- Website
- contouraviation.com
Flights from Denver to Williamson County Regional Airport via Chicago O'Hare
- Ave. Duration
- 5h 47m
- When
- Every day
- Estimated price
- $100–500
Flights from Denver to Williamson County Regional Airport via Omaha, Chicago O'Hare
- Ave. Duration
- 9h 10m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–500
Flights from Denver to Williamson County Regional Airport via Cedar Rapids, Chicago O'Hare
- Ave. Duration
- 9h 10m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–500
Flights from Denver to Williamson County Regional Airport via Kansas City, Chicago O'Hare
- Ave. Duration
- 9h 30m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $110–500
Flights from Denver to Williamson County Regional Airport via Des Moines, Chicago O'Hare
- Ave. Duration
- 9h 35m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–500
- Website
- flyfrontier.com
Flights from Denver to Lambert–St. Louis International Airport
- Ave. Duration
- 2h 11m
- When
- Every day
- Estimated price
- $180–310
Flights from Denver to Nashville
- Ave. Duration
- 2h 41m
- When
- Every day
- Estimated price
- $75–260
- Website
- aa.com
Flights from Denver to Williamson County Regional Airport via Kansas City, Chicago O'Hare
- Ave. Duration
- 11h 17m
- When
- Sunday
- Estimated price
- $110–500
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from St. Louis to Carbondale
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–45
- Website
- Amtrak
Bus from St. Louis to Carbondale
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–45
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from St. Louis to Carbondale
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a week
- Estimated price
- $14–23
- Schedules at
- Flixbus USA
Bus from St. Louis to Carbondale
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a week
- Estimated price
- $14–23
- Schedules at
- Flixbus USA
Bus from Nashville Bus Station to Carbondale Intermodal Station
- Ave. Duration
- 3h 55m
- Frequency
- 5 times a week
- Estimated price
- $30–50
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Denver Union Station to St Louis Bus Station
- Ave. Duration
- 16h 30m
- Frequency
- Twice daily
- Estimated price
- $120–250
- Website
- Greyhound
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More Questions & Answers
Yes, the driving distance between Denver to Murphysboro is 935 miles. It takes approximately 15h 16m to drive from Denver to Murphysboro.
Book your Denver to Murphysboro bus tickets online with Omio.
There are 31+ hotels available in Murphysboro.








