There are 4 ways to get from Denver to Murphysboro by plane, bus (Greyhound, Amtrak, Flixbus), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Williamson County Regional Airport
best- Fly from Denver (DEN) to Williamson County Regional Airport (MWA)plane DEN - MWA
7h 2m$178–481Bus
cheapest- Take the bus from Denver Union Station to St Louis Bus Stationbus Greyhound US1200 / ...
- Take the bus from St. Louis to Carbondalebus Amtrak Thruway Connecting Service
19h 40m$169–270Drive 929.6 mi
- Drive from Denver to Murphysborocar 929.6 mi
15h 16m$170–245Fly to Lambert–St. Louis International Airport, bus
- Fly from Denver (DEN) to Lambert–St. Louis International Airport (STL)plane DEN - STL
- Take the bus from St. Louis to Carbondalebus
7h 29m$216–561
Denver (DEN) to Williamson County Regional Airport (MWA) flights
Comparing Your Travel Options
The cheapest way to get from Denver to Murphysboro is to bus which costs $160 - $270 and takes 19h 40m.
The fastest way to get from Denver to Murphysboro is to fly which takes 7h 2m and costs $170 - $490.
No, there is no direct bus from Denver station to Murphysboro. However, there are services departing from Denver Union Station and arriving at Carbondale via St. Louis. The journey, including transfers, takes approximately 19h 40m.
The distance between Denver and Murphysboro is 903 miles. The road distance is 935 miles.
The best way to get from Denver to Murphysboro without a car is to bus which takes 19h 40m and costs $160 - $270.
It takes approximately 7h 2m to get from Denver to Murphysboro, including transfers.
Denver to Murphysboro bus services, operated by Greyhound USA, depart from Denver Union Station.
The best way to get from Denver to Murphysboro is to fly which takes 7h 2m and costs $170 - $490. Alternatively, you can bus, which costs $160 - $270 and takes 19h 40m.
Denver to Murphysboro bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Murphysboro is 1h ahead of Denver. It is currently 11:10 PM in Denver and 12:10 AM in Murphysboro.
What companies run services between Denver, CO, USA and Murphysboro, IL, USA?
American Airlines and Frontier Airlines fly from Denver (DEN) to Williamson County Regional Airport (MWA) twice daily. Alternatively, you can take a bus from Denver Union Station to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 19h 40m.
- Website
- southwest.com
Flights from Denver to Lambert–St. Louis International Airport
- Ave. Duration
- 2h
- When
- Every day
- Estimated price
- $95–550
Flights from Denver to Lambert–St. Louis International Airport via Omaha
- Ave. Duration
- 3h 25m
- When
- Sunday
- Estimated price
- $100–550
Flights from Denver to Lambert–St. Louis International Airport via Kansas City
- Ave. Duration
- 3h 35m
- When
- Tuesday and Wednesday
- Estimated price
- $95–550
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Denver Union Station to St Louis Bus Station
- Ave. Duration
- 16h 30m
- Frequency
- Twice daily
- Estimated price
- $130–220
- Website
- Greyhound
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Booking & Getting There
Yes, the driving distance between Denver to Murphysboro is 935 miles. It takes approximately 15h 16m to drive from Denver to Murphysboro.
Book your Denver to Murphysboro bus tickets online with Omio.
There are 35+ hotels available in Murphysboro.