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How to get fromDenver to Saint Charlesby plane, train (Amtrak), bus, taxi, or car

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There are 4 ways to get from Denver to Saint Charles by plane, train (Amtrak), bus, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Denver (DEN) to Des Moines (DSM)plane plane DEN - DSM
    3h 51m
    $170–675

  2. Drive 654.9 mi

    cheapest
    1. Drive from Denver to Saint Charlescar car 654.9 mi
    11h 1m
    $120–173

  3. Train (Amtrak)

    1. Take the train from Denver to Osceola Amtraktrain train California Zephyr
    12h 1m
    $260–501

  4. Bus, taxi

    1. Take the bus from Denver Union Station to Des Moinesbus bus Greyhound US0123S
    2. Take the taxi from Des Moines to Saint Charlestaxi taxi
    13h 41m
    $178–284

Denver (DEN) to Des Moines (DSM) flights

Calendar51Weekly Planes
Duration1h 46mAverage Duration
Ticket$112Cheapest Price
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Questions & Answers

Map of how to get from Denver to Saint Charles.ExpandLaunch map view
  • Distance: 635.2 mi
  • Duration: 3h 51m

What companies run services between Denver, CO, USA and Saint Charles, IA, USA?

United Airlines, Southwest Airlines, and Frontier Airlines fly from Denver (DEN) to Des Moines (DSM) every 4 hours. Alternatively, Amtrak operates a train from Denver to Osceola Amtrak once daily. Tickets cost $210–450 and the journey takes 11h 39m.

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